PDB entry 2gnh

View 2gnh on RCSB PDB site
Description: PKA five fold mutant model of Rho-kinase with H1152P
Class: transferase/transferase inhibitor
Keywords: PKA, surrogate, Rho-kinase, H1152P, inhibitor, TRANSFERASE/TRANSFERASE INHIBITOR COMPLEX
Deposited on 2006-04-10, released 2006-05-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.198
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-dependent protein kinase, alpha-catalytic subunit
    Species: Bos taurus [TaxId:9913]
    Gene: PRKACA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00517 (Start-349)
      • modified residue (9)
      • engineered (48)
      • engineered (122)
      • engineered (126)
      • engineered (180)
      • engineered (182)
      • modified residue (196)
      • modified residue (337)
    Domains in SCOPe 2.08: d2gnha_
  • Chain 'I':
    Compound: cAMP-dependent protein kinase inhibitor alpha
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Heterogens: H52, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2gnhA (A:)
gnaaaakkgseqesvkeflakakedflkkwenpaqntahldqferiktigtgsfgrvmlv
khmetgnhyamkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvm
eympggdmfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyi
kvadfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffa
dqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfatt
dwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

    Sequence, based on observed residues (ATOM records): (download) 
    >2gnhA (A:)
seqesvkeflakakedflkkwenpaqntahldqferiktigtgsfgrvmlvkhmetgnhy
amkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeympggdmf
shlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyikvadfgfak
rvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyek
ivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrk
veapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

  • Chain 'I':
    No sequence available.