PDB entry 2gmv

View 2gmv on RCSB PDB site
Description: PEPCK complex with a GTP-competitive inhibitor
Class: lyase
Keywords: GLUCONEOGENESIS, XANTHINE, INHIBITOR, Lyase
Deposited on 2006-04-07, released 2007-05-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-24, with a file datestamp of 2019-07-19.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phosphoenolpyruvate carboxykinase, cytosolic
    Species: Homo sapiens [TaxId:9606]
    Gene: PCK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35558 (Start-624)
      • variant (186)
      • variant (269)
      • variant (588)
      • variant (599)
    Domains in SCOPe 2.08: d2gmva1, d2gmva2
  • Chain 'B':
    Compound: Phosphoenolpyruvate carboxykinase, cytosolic
    Species: Homo sapiens [TaxId:9606]
    Gene: PCK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35558 (Start-624)
      • variant (186)
      • variant (269)
      • variant (588)
      • variant (599)
    Domains in SCOPe 2.08: d2gmvb1, d2gmvb2
  • Heterogens: MN, PEP, UN8, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2gmvA (A:)
    gelmppqlqnglnlsakvvqgsldslpqavreflennaelcqpdhihicdgseeengrll
    gqmeeegilrrlkkydncwlaltdprdvariesktvivtqeqrdtvpipktglsqlgrwm
    seedfekafnarfpgcmkgrtmyvipfsmgplgsplskigieltdspyvvasmrimtrmg
    tpvlealgdgefvkclhsvgcplplqkplvnnwpcnpeltliahlpdrreiisfgsgygg
    nsllgkkcfalrmasrlakeegwlaehmlvlgitnpegekkylaaafpsacgktnlammn
    pslpgwkvecvgddiawmkfdaqghlrainpengffgvapgtsvktnpnaiktiqkntif
    tnvaetsdggvywegideplasgvtitswknkewssedgepcahpnsrfctpasqcpiid
    aawespegvpiegiifggrrpagvplvyealswqhgvfvgaamrseataaaehkgkiimh
    dpfamrpffgynfgkylahwlsmaqhpaaklpkifhvnwfrkdkegkflwpgfgensrvl
    ewmfnridgkastkltpigyipkedalnlkglghinmmelfsiskefwdkevediekylv
    dqvnadlpceiereilalkqrisqm
    

    Sequence, based on observed residues (ATOM records): (download)
    >2gmvA (A:)
    nlsakvvqgsldslpqavreflennaelcqpdhihicdgseeengrllgqmeeegilrrl
    kkydncwlaltdprdvariesktvivtqeqrdtvpipktglsqlgrwmseedfekafnar
    fpgcmkgrtmyvipfsmgplgsplskigieltdspyvvasmrimtrmgtpvlealgdgef
    vkclhsvgcplplqkplvnnwpcnpeltliahlpdrreiisfgsgyggnsllgkkcfalr
    masrlakeegwlaehmlvlgitnpegekkylaaafpsacgktnlammnpslpgwkvecvg
    ddiawmkfdaqghlrainpengffgvapgtsvktnpnaiktiqkntiftnvaetsdggvy
    wegideplasgvtitswknkewssedgepcahpnsrfctpasqcpiidaawespegvpie
    giifggrrpagvplvyealswqhgvfvgaamrseakiimhdpfamrpffgynfgkylahw
    lsmaqhpaaklpkifhvnwfrkdkegkflwpgfgensrvlewmfnridgtkltpigyipk
    edalnlkglghinmmelfsiskefwdkevediekylvdqvnadlpceiereilalkqris
    qm
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2gmvB (B:)
    gelmppqlqnglnlsakvvqgsldslpqavreflennaelcqpdhihicdgseeengrll
    gqmeeegilrrlkkydncwlaltdprdvariesktvivtqeqrdtvpipktglsqlgrwm
    seedfekafnarfpgcmkgrtmyvipfsmgplgsplskigieltdspyvvasmrimtrmg
    tpvlealgdgefvkclhsvgcplplqkplvnnwpcnpeltliahlpdrreiisfgsgygg
    nsllgkkcfalrmasrlakeegwlaehmlvlgitnpegekkylaaafpsacgktnlammn
    pslpgwkvecvgddiawmkfdaqghlrainpengffgvapgtsvktnpnaiktiqkntif
    tnvaetsdggvywegideplasgvtitswknkewssedgepcahpnsrfctpasqcpiid
    aawespegvpiegiifggrrpagvplvyealswqhgvfvgaamrseataaaehkgkiimh
    dpfamrpffgynfgkylahwlsmaqhpaaklpkifhvnwfrkdkegkflwpgfgensrvl
    ewmfnridgkastkltpigyipkedalnlkglghinmmelfsiskefwdkevediekylv
    dqvnadlpceiereilalkqrisqm
    

    Sequence, based on observed residues (ATOM records): (download)
    >2gmvB (B:)
    nlsakvvqgsldslpqavreflennaelcqpdhihicdgseeengrllgqmeeegilrrl
    kkydncwlaltdprdvariesktvivtqeqrdtvpipktglsqlgrwmseedfekafnar
    fpgcmkgrtmyvipfsmgplgsplskigieltdspyvvasmrimtrmgtpvlealgdgef
    vkclhsvgcplplqkplvnnwpcnpeltliahlpdrreiisfgsgyggnsllgkkcfalr
    masrlakeegwlaehmlvlgitnpegekkylaaafpsacgktnlammnpslpgwkvecvg
    ddiawmkfdaqghlrainpengffgvapgtsvktnpnaiktiqkntiftnvaetsdggvy
    wegideplasgvtitswknkewssedgepcahpnsrfctpasqcpiidaawespegvpie
    giifggrrpagvplvyealswqhgvfvgaamrseakiimhdpfamrpffgynfgkylahw
    lsmaqhpaaklpkifhvnwfrkdkegkflwpgfgensrvlewmfnridgtkltpigyipk
    edalnlkglghinmmelfsiskefwdkevediekylvdqvnadlpceiereilalkqris
    qm