PDB entry 2gm1

View 2gm1 on RCSB PDB site
Description: Crystal structure of the mitotic kinesin eg5 in complex with mg-adp and n-(3-aminopropyl)-n-((3-benzyl-5-chloro-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)(cyclopropyl)methyl)-4-methylbenzamide
Class: Cell Cycle
Keywords: Eg5 Mg-ADP Complex Inhibitor, Cell Cycle
Deposited on 2006-04-05, released 2006-06-27
The last revision prior to the SCOPe 2.02 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.23
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: kinesin-related motor protein eg5
    Species: Homo sapiens [TaxId:9606]
    Gene: EG5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d2gm1a_
  • Chain 'B':
    Compound: kinesin-related motor protein eg5
    Species: Homo sapiens [TaxId:9606]
    Gene: EG5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d2gm1b_
  • Chain 'D':
    Compound: kinesin-related motor protein eg5
    Species: Homo sapiens [TaxId:9606]
    Gene: EG5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d2gm1d_
  • Chain 'E':
    Compound: kinesin-related motor protein eg5
    Species: Homo sapiens [TaxId:9606]
    Gene: EG5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d2gm1e_
  • Heterogens: MG, 2AZ, ADP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2gm1A (A:)
masqpnssakkkeekgkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladk
ssrktytfdmvfgastkqidvyrsvvcpildevimgynctifaygqtgtgktftmegers
pneeytweedplagiiprtlhqifekltdngtefsvkvslleiyneelfdllnpssdvse
rlqmfddprnkrgviikgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfs
vtihmkettidgeelvkigklnlvdlagsenigrsgavdkrareagninqslltlgrvit
alvertphvpyreskltrilqdslggrtrtsiiatispaslnleetlstleyahraknil
nkpevnqk

    Sequence, based on observed residues (ATOM records): (download) 
    >2gm1A (A:)
kniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtgglkssrktytfdmvfgastkq
idvyrsvvcpildevimgynctifaygqtgtgktftmegerspneeytweedplagiipr
tlhqifekltdngtefsvkvslleiyneelfdllnpssdvserlqmfddprnkrgviikg
leeitvhnkdevyqilekgaakrttaatlmnayssrshsvfsvtihmkevkigklnlvdl
agsenigrinqslltlgrvitalvertphvpyreskltrilqdslggrtrtsiiatispa
slnleetlstleyahraknilnkpevnq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2gm1B (B:)
masqpnssakkkeekgkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladk
ssrktytfdmvfgastkqidvyrsvvcpildevimgynctifaygqtgtgktftmegers
pneeytweedplagiiprtlhqifekltdngtefsvkvslleiyneelfdllnpssdvse
rlqmfddprnkrgviikgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfs
vtihmkettidgeelvkigklnlvdlagsenigrsgavdkrareagninqslltlgrvit
alvertphvpyreskltrilqdslggrtrtsiiatispaslnleetlstleyahraknil
nkpevnqk

    Sequence, based on observed residues (ATOM records): (download) 
    >2gm1B (B:)
kniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladkssrktytfdmvfgast
kqidvyrsvvcpildevimgynctifaygqtgtgktftmegerspneeytweedplagii
prtlhqifekltdngtefsvkvslleiyneelfdllnpssdvserlqmfddprnkrgvii
kgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfsvtihmkvkigklnlvd
lagseninqslltlgrvitalvertphvpyreskltrilqdslggrtrtsiiatispasl
nleetlstleyahraknilnk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2gm1D (D:)
masqpnssakkkeekgkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladk
ssrktytfdmvfgastkqidvyrsvvcpildevimgynctifaygqtgtgktftmegers
pneeytweedplagiiprtlhqifekltdngtefsvkvslleiyneelfdllnpssdvse
rlqmfddprnkrgviikgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfs
vtihmkettidgeelvkigklnlvdlagsenigrsgavdkrareagninqslltlgrvit
alvertphvpyreskltrilqdslggrtrtsiiatispaslnleetlstleyahraknil
nkpevnqk

    Sequence, based on observed residues (ATOM records): (download) 
    >2gm1D (D:)
gkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtgglkssrktytfdmvfgastk
qidvyrsvvcpildevimgynctifaygqtgtgktftmegerspneeytweedplagiip
rtlhqifekltdngtefsvkvslleiyneelfdllnpssdvserlqmfddprnkrgviik
gleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfsvtihmkvkigklnlvdl
agseninqslltlgrvitalvertphvpyreskltrilqdslggrtrtsiiatispasln
leetlstleyahraknilnkpevnq

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2gm1E (E:)
masqpnssakkkeekgkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladk
ssrktytfdmvfgastkqidvyrsvvcpildevimgynctifaygqtgtgktftmegers
pneeytweedplagiiprtlhqifekltdngtefsvkvslleiyneelfdllnpssdvse
rlqmfddprnkrgviikgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfs
vtihmkettidgeelvkigklnlvdlagsenigrsgavdkrareagninqslltlgrvit
alvertphvpyreskltrilqdslggrtrtsiiatispaslnleetlstleyahraknil
nkpevnqk

    Sequence, based on observed residues (ATOM records): (download) 
    >2gm1E (E:)
kniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtgssrktytfdmvfgastkqidv
yrsvvcpildevimgynctifaygqtgtgktftmegerspneeytweedplagiiprtlh
qifekltdngtefsvkvslleiyneelfdllnpssdvserlqmfddprnkrgviikglee
itvhnkdevyqilekgaakrttaatlmnayssrshsvfsvtihmkvkigklnlvdlagse
nininqslltlgrvitalvertphvpyreskltrilqdslggrtrtsiiatispaslnle
etlstleyahraknilnkpevnq