PDB entry 2gjx

View 2gjx on RCSB PDB site
Description: Crystallographic structure of human beta-Hexosaminidase A
Class: hydrolase
Keywords: beta-hexosaminidase A, glycosidase, Tay-Sachs disease, GM2 ganglisode, Tim barrel
Deposited on 2006-03-31, released 2006-06-20
The last revision prior to the SCOP 1.73 freeze date was dated 2006-06-20, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.27
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-hexosaminidase alpha chain
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: beta-hexosaminidase beta chain
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2gjxb1, d2gjxb2
  • Chain 'C':
    Compound: beta-hexosaminidase beta chain
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2gjxc1, d2gjxc2
  • Chain 'D':
    Compound: Beta-hexosaminidase alpha chain
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Beta-hexosaminidase alpha chain
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: beta-hexosaminidase beta chain
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2gjxf1, d2gjxf2
  • Chain 'G':
    Compound: beta-hexosaminidase beta chain
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2gjxg1, d2gjxg2
  • Chain 'H':
    Compound: Beta-hexosaminidase alpha chain
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NAG, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2gjxB (B:)
akpgpalwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgfy
kwhhepaefqaktqvqqllvsitlqsecdafpnissdesytllvkepvavlkanrvwgal
rgletfsqlvyqdsygtftinestiidsprfshrgilidtsrhylpvkiilktldamafn
kfnvlhwhivddqsfpyqsitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpef
dtpghtlswgkgqkdlltpcysrqnkldsfgpinptlnttysflttffkeisevfpdqfi
hlggdevefkcwesnpkiqdfmrqkgfgtdfkklesfyiqkvldiiatinkgsivwqevf
ddkaklapgtivevwkdsaypeelsrvtasgfpvilsapwyldlisygqdwrkyykvepl
dfggtqkqkqlfiggeaclwgeyvdatnltprlwprasavgerlwsskdvrdmddaydrl
trhrcrmvergiaaqplyagycnhenm

    Sequence, based on observed residues (ATOM records): (download) 
    >2gjxB (B:)
palwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgtqvqql
lvsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvyqdsygtf
tinestiidsprfshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyq
sitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdllt
pcysdsfgpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmr
qkgfgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypee
lsrvtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgey
vdatnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2gjxC (C:)
akpgpalwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgfy
kwhhepaefqaktqvqqllvsitlqsecdafpnissdesytllvkepvavlkanrvwgal
rgletfsqlvyqdsygtftinestiidsprfshrgilidtsrhylpvkiilktldamafn
kfnvlhwhivddqsfpyqsitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpef
dtpghtlswgkgqkdlltpcysrqnkldsfgpinptlnttysflttffkeisevfpdqfi
hlggdevefkcwesnpkiqdfmrqkgfgtdfkklesfyiqkvldiiatinkgsivwqevf
ddkaklapgtivevwkdsaypeelsrvtasgfpvilsapwyldlisygqdwrkyykvepl
dfggtqkqkqlfiggeaclwgeyvdatnltprlwprasavgerlwsskdvrdmddaydrl
trhrcrmvergiaaqplyagycnhenm

    Sequence, based on observed residues (ATOM records): (download) 
    >2gjxC (C:)
palwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgtqvqql
lvsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvyqdsygtf
tinestiidsprfshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyq
sitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdllt
pcysldsfgpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfm
rqkgfgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaype
elsrvtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwge
yvdatnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagyc
n

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2gjxF (F:)
akpgpalwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgfy
kwhhepaefqaktqvqqllvsitlqsecdafpnissdesytllvkepvavlkanrvwgal
rgletfsqlvyqdsygtftinestiidsprfshrgilidtsrhylpvkiilktldamafn
kfnvlhwhivddqsfpyqsitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpef
dtpghtlswgkgqkdlltpcysrqnkldsfgpinptlnttysflttffkeisevfpdqfi
hlggdevefkcwesnpkiqdfmrqkgfgtdfkklesfyiqkvldiiatinkgsivwqevf
ddkaklapgtivevwkdsaypeelsrvtasgfpvilsapwyldlisygqdwrkyykvepl
dfggtqkqkqlfiggeaclwgeyvdatnltprlwprasavgerlwsskdvrdmddaydrl
trhrcrmvergiaaqplyagycnhenm

    Sequence, based on observed residues (ATOM records): (download) 
    >2gjxF (F:)
palwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgtqvqql
lvsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvyqdsygtf
tinestiidsprfshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyq
sitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdllt
pcysdsfgpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmr
qkgfgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypee
lsrvtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgey
vdatnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >2gjxG (G:)
akpgpalwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgfy
kwhhepaefqaktqvqqllvsitlqsecdafpnissdesytllvkepvavlkanrvwgal
rgletfsqlvyqdsygtftinestiidsprfshrgilidtsrhylpvkiilktldamafn
kfnvlhwhivddqsfpyqsitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpef
dtpghtlswgkgqkdlltpcysrqnkldsfgpinptlnttysflttffkeisevfpdqfi
hlggdevefkcwesnpkiqdfmrqkgfgtdfkklesfyiqkvldiiatinkgsivwqevf
ddkaklapgtivevwkdsaypeelsrvtasgfpvilsapwyldlisygqdwrkyykvepl
dfggtqkqkqlfiggeaclwgeyvdatnltprlwprasavgerlwsskdvrdmddaydrl
trhrcrmvergiaaqplyagycnhenm

    Sequence, based on observed residues (ATOM records): (download) 
    >2gjxG (G:)
palwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgtqvqql
lvsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvyqdsygtf
tinestiidsprfshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyq
sitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdllt
pcysdsfgpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmr
qkgfgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypee
lsrvtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgey
vdatnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycn

  • Chain 'H':
    No sequence available.