PDB entry 2gd6

View 2gd6 on RCSB PDB site
Description: The 1,1-proton transfer reaction mechanism by alpha-methylacyl-CoA racemase is catalyzed by an aspartate/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety
Class: isomerase
Keywords: Alpha-methylacyl-CoA racemase, racemase, CoA transferase, proton transfer, Coenzyme A, ISOMERASE
Deposited on 2006-03-15, released 2007-02-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-18, with a file datestamp of 2017-10-13.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: probable alpha-methylacyl-CoA racemase MCR
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: CAB09301
    Database cross-references and differences (RAF-indexed):
    • GB CAB09031 (Start-359)
    Domains in SCOPe 2.08: d2gd6a_
  • Chain 'B':
    Compound: probable alpha-methylacyl-CoA racemase MCR
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: CAB09301
    Database cross-references and differences (RAF-indexed):
    • GB CAB09031 (Start-359)
    Domains in SCOPe 2.08: d2gd6b_
  • Chain 'C':
    Compound: probable alpha-methylacyl-CoA racemase MCR
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: CAB09301
    Database cross-references and differences (RAF-indexed):
    • GB CAB09031 (Start-359)
    Domains in SCOPe 2.08: d2gd6c_
  • Chain 'D':
    Compound: probable alpha-methylacyl-CoA racemase MCR
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: CAB09301
    Database cross-references and differences (RAF-indexed):
    • GB CAB09031 (Start-359)
    Domains in SCOPe 2.08: d2gd6d_
  • Heterogens: ACO, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2gd6A (A:)
magplsglrvvelagigpgphaamilgdlgadvvridrpssvdgisrdamlrnrrivtad
lksdqglelalkliakadvliegyrpgvterlglgpeecakvndrliyarmtgwgqtgpr
sqqaghdinyislngilhaigrgderpvpplnlvgdfgggsmfllvgilaalwerqssgk
gqvvdaamvdgssvliqmmwamratgmwtdtrganmldggapyydtyecadgryvavgai
epqfyaamlaglgldaaelppqndrarwpelrallteafashdrdhwgavfansdacvtp
vlafgevhnephiierntfyeanggwqpmpaprfsrtassqprppaatidieavltdwdg

    Sequence, based on observed residues (ATOM records): (download) 
    >2gd6A (A:)
agplsglrvvelagigpgphaamilgdlgadvvridrpisrdamlrnrrivtadlksdqg
lelalkliakadvliegyrpgvterlglgpeecakvndrliyarmtgwgqtgprsqqagh
dinyislngilhaigrgderpvpplnlvgdfgggsmfllvgilaalwerqssgkgqvvda
amvdgssvliqmmwamratgmwtdtrganmldggapyydtyecadgryvavgaiepqfya
amlaglgldaaelppqndrarwpelrallteafashdrdhwgavfansdacvtpvlafge
vhnephiierntfyeanggwqpmpaprfsrtassqprppaatidieavltdwdg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2gd6B (B:)
magplsglrvvelagigpgphaamilgdlgadvvridrpssvdgisrdamlrnrrivtad
lksdqglelalkliakadvliegyrpgvterlglgpeecakvndrliyarmtgwgqtgpr
sqqaghdinyislngilhaigrgderpvpplnlvgdfgggsmfllvgilaalwerqssgk
gqvvdaamvdgssvliqmmwamratgmwtdtrganmldggapyydtyecadgryvavgai
epqfyaamlaglgldaaelppqndrarwpelrallteafashdrdhwgavfansdacvtp
vlafgevhnephiierntfyeanggwqpmpaprfsrtassqprppaatidieavltdwdg

    Sequence, based on observed residues (ATOM records): (download) 
    >2gd6B (B:)
agplsglrvvelagigpgphaamilgdlgadvvridrpisrdamlrnrrivtadlksdqg
lelalkliakadvliegyrpgvterlglgpeecakvndrliyarmtgwgqtgprsqqagh
dinyislngilhaigrgderpvpplnlvgdfgggsmfllvgilaalwerqssgkgqvvda
amvdgssvliqmmwamratgmwtdtrganmldggapyydtyecadgryvavgaiepqfya
amlaglgldaaelppqndrarwpelrallteafashdrdhwgavfansdacvtpvlafge
vhnephiierntfyeanggwqpmpaprfsrtassqprppaatidieavltdwdg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2gd6C (C:)
magplsglrvvelagigpgphaamilgdlgadvvridrpssvdgisrdamlrnrrivtad
lksdqglelalkliakadvliegyrpgvterlglgpeecakvndrliyarmtgwgqtgpr
sqqaghdinyislngilhaigrgderpvpplnlvgdfgggsmfllvgilaalwerqssgk
gqvvdaamvdgssvliqmmwamratgmwtdtrganmldggapyydtyecadgryvavgai
epqfyaamlaglgldaaelppqndrarwpelrallteafashdrdhwgavfansdacvtp
vlafgevhnephiierntfyeanggwqpmpaprfsrtassqprppaatidieavltdwdg

    Sequence, based on observed residues (ATOM records): (download) 
    >2gd6C (C:)
agplsglrvvelagigpgphaamilgdlgadvvridrpisrdamlrnrrivtadlksdqg
lelalkliakadvliegyrpgvterlglgpeecakvndrliyarmtgwgqtgprsqqagh
dinyislngilhaigrgderpvpplnlvgdfgggsmfllvgilaalwerqssgkgqvvda
amvdgssvliqmmwamratgmwtdtrganmldggapyydtyecadgryvavgaiepqfya
amlaglgldaaelppqndrarwpelrallteafashdrdhwgavfansdacvtpvlafge
vhnephiierntfyeanggwqpmpaprfsrtassqprppaatidieavltdwdg

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2gd6D (D:)
magplsglrvvelagigpgphaamilgdlgadvvridrpssvdgisrdamlrnrrivtad
lksdqglelalkliakadvliegyrpgvterlglgpeecakvndrliyarmtgwgqtgpr
sqqaghdinyislngilhaigrgderpvpplnlvgdfgggsmfllvgilaalwerqssgk
gqvvdaamvdgssvliqmmwamratgmwtdtrganmldggapyydtyecadgryvavgai
epqfyaamlaglgldaaelppqndrarwpelrallteafashdrdhwgavfansdacvtp
vlafgevhnephiierntfyeanggwqpmpaprfsrtassqprppaatidieavltdwdg

    Sequence, based on observed residues (ATOM records): (download) 
    >2gd6D (D:)
agplsglrvvelagigpgphaamilgdlgadvvridrpisrdamlrnrrivtadlksdqg
lelalkliakadvliegyrpgvterlglgpeecakvndrliyarmtgwgqtgprsqqagh
dinyislngilhaigrgderpvpplnlvgdfgggsmfllvgilaalwerqssgkgqvvda
amvdgssvliqmmwamratgmwtdtrganmldggapyydtyecadgryvavgaiepqfya
amlaglgldaaelppqndrarwpelrallteafashdrdhwgavfansdacvtpvlafge
vhnephiierntfyeanggwqpmpaprfsrtassqprppaatidieavltdwdg