PDB entry 2gd2

View 2gd2 on RCSB PDB site
Description: The 1,1-proton transfer reaction mechanism by alpha-methylacyl-CoA racemase is catalyzed by an aspartate/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety
Class: isomerase
Keywords: Alpha-methylacyl-CoA racemase, racemase, CoA transferase, proton transfer, Coenzyme A, ISOMERASE
Deposited on 2006-03-15, released 2007-02-20
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.208
AEROSPACI score: 0.52 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: probable alpha-methylacyl-CoA racemase MCR
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: CAB09031
    Database cross-references and differences (RAF-indexed):
    • GB CAB09031 (Start-359)
    Domains in SCOPe 2.06: d2gd2a_
  • Chain 'B':
    Compound: probable alpha-methylacyl-CoA racemase MCR
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: CAB09031
    Database cross-references and differences (RAF-indexed):
    • GB CAB09031 (Start-359)
    Domains in SCOPe 2.06: d2gd2b_
  • Chain 'C':
    Compound: probable alpha-methylacyl-CoA racemase MCR
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: CAB09031
    Database cross-references and differences (RAF-indexed):
    • GB CAB09031 (Start-359)
    Domains in SCOPe 2.06: d2gd2c_
  • Chain 'D':
    Compound: probable alpha-methylacyl-CoA racemase MCR
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: CAB09031
    Database cross-references and differences (RAF-indexed):
    • GB CAB09031 (Start-359)
    Domains in SCOPe 2.06: d2gd2d_
  • Heterogens: CAA, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2gd2A (A:)
    magplsglrvvelagigpgphaamilgdlgadvvridrpssvdgisrdamlrnrrivtad
    lksdqglelalkliakadvliegyrpgvterlglgpeecakvndrliyarmtgwgqtgpr
    sqqaghdinyislngilhaigrgderpvpplnlvgdfgggsmfllvgilaalwerqssgk
    gqvvdaamvdgssvliqmmwamratgmwtdtrganmldggapyydtyecadgryvavgai
    epqfyaamlaglgldaaelppqndrarwpelrallteafashdrdhwgavfansdacvtp
    vlafgevhnephiierntfyeanggwqpmpaprfsrtassqprppaatidieavltdwdg
    

    Sequence, based on observed residues (ATOM records): (download)
    >2gd2A (A:)
    agplsglrvvelagigpgphaamilgdlgadvvridrpisrdamlrnrrivtadlksdqg
    lelalkliakadvliegyrpgvterlglgpeecakvndrliyarmtgwgqtgprsqqagh
    dinyislngilhaigrgderpvpplnlvgdfgggsmfllvgilaalwerqssgkgqvvda
    amvdgssvliqmmwamratgmwtdtrganmldggapyydtyecadgryvavgaiepqfya
    amlaglgldaaelppqndrarwpelrallteafashdrdhwgavfansdacvtpvlafge
    vhnephiierntfyeanggwqpmpaprfsrtassqprppaatidieavltdwdg
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2gd2B (B:)
    magplsglrvvelagigpgphaamilgdlgadvvridrpssvdgisrdamlrnrrivtad
    lksdqglelalkliakadvliegyrpgvterlglgpeecakvndrliyarmtgwgqtgpr
    sqqaghdinyislngilhaigrgderpvpplnlvgdfgggsmfllvgilaalwerqssgk
    gqvvdaamvdgssvliqmmwamratgmwtdtrganmldggapyydtyecadgryvavgai
    epqfyaamlaglgldaaelppqndrarwpelrallteafashdrdhwgavfansdacvtp
    vlafgevhnephiierntfyeanggwqpmpaprfsrtassqprppaatidieavltdwdg
    

    Sequence, based on observed residues (ATOM records): (download)
    >2gd2B (B:)
    agplsglrvvelagigpgphaamilgdlgadvvridrpisrdamlrnrrivtadlksdqg
    lelalkliakadvliegyrpgvterlglgpeecakvndrliyarmtgwgqtgprsqqagh
    dinyislngilhaigrgderpvpplnlvgdfgggsmfllvgilaalwerqssgkgqvvda
    amvdgssvliqmmwamratgmwtdtrganmldggapyydtyecadgryvavgaiepqfya
    amlaglgldaaelppqndrarwpelrallteafashdrdhwgavfansdacvtpvlafge
    vhnephiierntfyeanggwqpmpaprfsrtassqprppaatidieavltdwdg
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >2gd2C (C:)
    magplsglrvvelagigpgphaamilgdlgadvvridrpssvdgisrdamlrnrrivtad
    lksdqglelalkliakadvliegyrpgvterlglgpeecakvndrliyarmtgwgqtgpr
    sqqaghdinyislngilhaigrgderpvpplnlvgdfgggsmfllvgilaalwerqssgk
    gqvvdaamvdgssvliqmmwamratgmwtdtrganmldggapyydtyecadgryvavgai
    epqfyaamlaglgldaaelppqndrarwpelrallteafashdrdhwgavfansdacvtp
    vlafgevhnephiierntfyeanggwqpmpaprfsrtassqprppaatidieavltdwdg
    

    Sequence, based on observed residues (ATOM records): (download)
    >2gd2C (C:)
    agplsglrvvelagigpgphaamilgdlgadvvridrpisrdamlrnrrivtadlksdqg
    lelalkliakadvliegyrpgvterlglgpeecakvndrliyarmtgwgqtgprsqqagh
    dinyislngilhaigrgderpvpplnlvgdfgggsmfllvgilaalwerqssgkgqvvda
    amvdgssvliqmmwamratgmwtdtrganmldggapyydtyecadgryvavgaiepqfya
    amlaglgldaaelppqndrarwpelrallteafashdrdhwgavfansdacvtpvlafge
    vhnephiierntfyeanggwqpmpaprfsrtassqprppaatidieavltdwdg
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >2gd2D (D:)
    magplsglrvvelagigpgphaamilgdlgadvvridrpssvdgisrdamlrnrrivtad
    lksdqglelalkliakadvliegyrpgvterlglgpeecakvndrliyarmtgwgqtgpr
    sqqaghdinyislngilhaigrgderpvpplnlvgdfgggsmfllvgilaalwerqssgk
    gqvvdaamvdgssvliqmmwamratgmwtdtrganmldggapyydtyecadgryvavgai
    epqfyaamlaglgldaaelppqndrarwpelrallteafashdrdhwgavfansdacvtp
    vlafgevhnephiierntfyeanggwqpmpaprfsrtassqprppaatidieavltdwdg
    

    Sequence, based on observed residues (ATOM records): (download)
    >2gd2D (D:)
    agplsglrvvelagigpgphaamilgdlgadvvridrpisrdamlrnrrivtadlksdqg
    lelalkliakadvliegyrpgvterlglgpeecakvndrliyarmtgwgqtgprsqqagh
    dinyislngilhaigrgderpvpplnlvgdfgggsmfllvgilaalwerqssgkgqvvda
    amvdgssvliqmmwamratgmwtdtrganmldggapyydtyecadgryvavgaiepqfya
    amlaglgldaaelppqndrarwpelrallteafashdrdhwgavfansdacvtpvlafge
    vhnephiierntfyeanggwqpmpaprfsrtassqprppaatidieavltdwdg