PDB entry 2g8o
View 2g8o on RCSB PDB site
Description: High resolution structure of Escherichia coli thymidylate synthase ternary complex with dUMP and a cofactor analog, CB3717
Class: transferase
Keywords: methyltransferase, dUMP, antifolate, high-resolution, ternary complex, beta sheet, alpha/beta protein
Deposited on
2006-03-02, released
2006-03-14
The last revision prior to the SCOP 1.73 freeze date was dated
2006-03-14, with a file datestamp of
2007-06-28.
Experiment type: XRAY
Resolution: 1.3 Å
R-factor: 0.152
AEROSPACI score: 0.62
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Thymidylate synthase
Species: Escherichia coli
Gene: thyA
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.73: d2g8oa1 - Chain 'B':
Compound: Thymidylate synthase
Species: Escherichia coli
Gene: thyA
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.73: d2g8ob1 - Heterogens: UMP, CB3, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>2g8oA (A:)
mkqylelmqkvldegtqkndrtgtgtlsifghqmrfnlqdgfplvttkrchlrsiihell
wflqgdtniaylhennvtiwdewadengdlgpvygkqwrawptpdgrhidqittvlnqlk
ndpdsrriivsawnvgeldkmalapchaffqfyvadgklscqlyqrscdvflglpfnias
yallvhmmaqqcdlevgdfvwtggdthlysnhmdqthlqlsreprplpkliikrkpesif
dyrfedfeiegydphpgikapvai
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>2g8oB (B:)
mkqylelmqkvldegtqkndrtgtgtlsifghqmrfnlqdgfplvttkrchlrsiihell
wflqgdtniaylhennvtiwdewadengdlgpvygkqwrawptpdgrhidqittvlnqlk
ndpdsrriivsawnvgeldkmalapchaffqfyvadgklscqlyqrscdvflglpfnias
yallvhmmaqqcdlevgdfvwtggdthlysnhmdqthlqlsreprplpkliikrkpesif
dyrfedfeiegydphpgikapvai