PDB entry 2g8e
View 2g8e on RCSB PDB site
Description: Calpain 1 proteolytic core in complex with SNJ-1715, a cyclic hemiacetal-type inhibitor
Class: hydrolase/hydrolase inhibitor
Keywords: protease, peptidase, inhibitor, cyclic hemiacetal, aldehyde, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on
2006-03-02, released
2006-06-06
The last revision prior to the SCOPe 2.03 freeze date was dated
2012-03-14, with a file datestamp of
2012-03-09.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.181
AEROSPACI score: 0.39
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Calpain-1 catalytic subunit
Species: Rattus norvegicus [TaxId:10116]
Gene: Capn1, Cls1
Database cross-references and differences (RAF-indexed):
- Uniprot P97571 (Start-330)
- cloning artifact (331-332)
Domains in SCOPe 2.03: d2g8ea_ - Heterogens: CA, 0M6, MES, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2g8eA (A:)
mglgrhenaikylgqdyenlrarclqngvlfqddafppvshslgfkelgpnssktygikw
krptellsnpqfivdgatrtdicqgalgdcwllaaiasltlnetilhrvvpygqsfqegy
agifhfqlwqfgewvdvvvddllptkdgklvfvhsaqgnefwsallekayakvngsyeal
sggctseafedftggvtewydlqkapsdlyqiilkalergsllgcsinisdirdleaitf
knlvrghaysvtdakqvtyqgqrvnlirmrnpwgevewkgpwsdnsyewnkvdpyereql
rvkmedgefwmsfrdfireftkleicnltpdlehhhhhh
Sequence, based on observed residues (ATOM records): (download)
>2g8eA (A:)
naikylgqdyenlrarclqngvlfqddafppvshslgfkelgpnssktygikwkrptell
snpqfivdgatrtdicqgalgdcwllaaiasltlnetilhrvvpygqsfqegyagifhfq
lwqfgewvdvvvddllptkdgklvfvhsaqgnefwsallekayakvngsyealsggctse
afedftggvtewydlqkapsdlyqiilkalergsllgcsinisdirdleaitfknlvrgh
aysvtdakqvtyqgqrvnlirmrnpwgevewkgpwsdnsyewnkvdpyereqlrvkmedg
efwmsfrdfireftkleicnltpdle