PDB entry 2fy4

View 2fy4 on RCSB PDB site
Description: Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis
Class: transferase
Keywords: two domain, alpha-beta protein, transferase, coenzyme A
Deposited on 2006-02-07, released 2006-12-12
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.203
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: choline O-acetyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: CHAT
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28329
      • engineered (224-226)
      • see remark 999 (345-346)
      • see remark 999 (348)
      • see remark 999 (350-352)
      • see remark 999 (354)
      • engineered (514-515)
      • engineered (578-579)
    Domains in SCOPe 2.06: d2fy4a1, d2fy4a2
  • Heterogens: COA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2fy4A (A:)
aaaktpsseesglpklpvpplqqtlatylqcmrhlvseeqfrksqaivqqfgapgglget
lqqkllerqektanwvseywlndmylnnrlalpvnsspavifarqhfpgtddqlrfaasl
isgvlsykalldshsiptdcakgqlsgqplcmkqyyglfssyrlpghtqdtlvaqnssim
pepehvivaccnqffvldvvinfrrlsegdlftqlrkivkmasnaaarlppiglltsdgr
sewaeartvlvkdstnrdsldmierciclvcldapggvelsdthralqllhgggysknga
nrwydkslqfvvgrdgtcgvvcehspfdgivlvqctehllkhmtqpelvrspmvplpapr
rlrwkcspeiqghlassaeklqrivknldfivykfdnygktfikkqkcspdafiqvalql
afyrlhrrlvptyesasirrfqegrvdnirsatpealafvravtdhkaavpasekllllk
dairaqtaytvmaitgmaidnhllalrelaramcaalpemfmdetylmsnrfvlstsqvp
tttemfccygpvvpngygacynpqpetilfcissfhscaatssskfakaveeslidmrdl
csllppteskpl

    Sequence, based on observed residues (ATOM records): (download) 
    >2fy4A (A:)
sglpklpvpplqqtlatylqcmrhlvseeqfrksqaivqqfgapgglgetlqqkllerqe
ktanwvseywlndmylnnrlalpvnsspavifarqhfpgtddqlrfaaslisgvlsykal
ldshsiptdcakgqlsgqplcmkqyyglfssyrlpghtqdtlvaqmpepehvivaccnqf
fvldvvinfrrlsegdlftqlrkivkmasnaaarlppiglltsdgrsewaeartvlvkds
tnrdsldmierciclvcldapggvelsdthralqllhgggysknganrwydkslqfvvgr
dgtcgvvcehspfdgivlvqctehllkhmtqpelvrspmvplpaprrlrwkcspeiqghl
assaeklqrivknldfivykfdnygktfikkqkcspdafiqvalqlafyrlhrrlvptye
sasirrfqegrvdnirsatpealafvravtdhkaavpasekllllkdairaqtaytvmai
tgmaidnhllalrelaramcaalpemfmdetylmsnrfvlstsqvptttemfccygpvvp
ngygacynpqpetilfcissfhscaatssskfakaveeslidmrdlcsl