PDB entry 2fx8

View 2fx8 on RCSB PDB site
Description: Crystal structure of hiv-1 neutralizing human fab 4e10 in complex with an aib-induced peptide encompassing the 4e10 epitope on gp41
Class: immune system
Keywords: immunoglobulin fold, beta-sandwich, antibody-epitope complex, IMMUNE SYSTEM
Deposited on 2006-02-03, released 2006-12-19
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.235
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Fab 4E10
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2FX8 (0-226)
    Domains in SCOPe 2.03: d2fx8h1, d2fx8h2
  • Chain 'I':
    Compound: Fab 4E10
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2FX8 (0-226)
    Domains in SCOPe 2.03: d2fx8i1, d2fx8i2
  • Chain 'J':
    Compound: Fab 4E10
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2FX8 (0-226)
    Domains in SCOPe 2.03: d2fx8j1, d2fx8j2
  • Chain 'K':
    Compound: Fab 4E10
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2FX8 (0-226)
    Domains in SCOPe 2.03: d2fx8k1, d2fx8k2
  • Chain 'L':
    Compound: Fab 4E10
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2FX8 (0-213)
    Domains in SCOPe 2.03: d2fx8l1, d2fx8l2
  • Chain 'M':
    Compound: Fab 4E10
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2FX8 (0-213)
    Domains in SCOPe 2.03: d2fx8m1, d2fx8m2
  • Chain 'N':
    Compound: Fab 4E10
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2FX8 (0-213)
    Domains in SCOPe 2.03: d2fx8n1, d2fx8n2
  • Chain 'O':
    Compound: Fab 4E10
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2FX8 (0-213)
    Domains in SCOPe 2.03: d2fx8o1, d2fx8o2
  • Chain 'P':
    Compound: Fragment of HIV glycoprotein (GP41)
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05880 (0-11)
      • modified residue (7)
      • engineered (10-11)
  • Chain 'Q':
    Compound: Fragment of HIV glycoprotein (GP41)
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05880 (0-11)
      • modified residue (7)
      • engineered (10-11)
  • Chain 'R':
    Compound: Fragment of HIV glycoprotein (GP41)
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05880 (0-11)
      • modified residue (7)
      • engineered (10-11)
  • Chain 'S':
    Compound: Fragment of HIV glycoprotein (GP41)
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05880 (0-11)
      • modified residue (7)
      • engineered (10-11)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2fx8H (H:)
qvqlvqsgaevkrpgssvtvsckasggsfstyalswvrqapgrglewmggviplltitny
aprfqgrititadrststaylelnslrpedtavyycaregttgwgwlgkpigafahwgqg
tlvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtf
pavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2fx8I (I:)
qvqlvqsgaevkrpgssvtvsckasggsfstyalswvrqapgrglewmggviplltitny
aprfqgrititadrststaylelnslrpedtavyycaregttgwgwlgkpigafahwgqg
tlvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtf
pavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2fx8J (J:)
qvqlvqsgaevkrpgssvtvsckasggsfstyalswvrqapgrglewmggviplltitny
aprfqgrititadrststaylelnslrpedtavyycaregttgwgwlgkpigafahwgqg
tlvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtf
pavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'K':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2fx8K (K:)
qvqlvqsgaevkrpgssvtvsckasggsfstyalswvrqapgrglewmggviplltitny
aprfqgrititadrststaylelnslrpedtavyycaregttgwgwlgkpigafahwgqg
tlvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtf
pavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2fx8L (L:)
eivltqspgtqslspgeratlscrasqsvgnnklawyqqrpgqaprlliygassrpsgva
drfsgsgsgtdftltisrlepedfavyycqqygqslstfgqgtkvevkrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'M':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2fx8M (M:)
eivltqspgtqslspgeratlscrasqsvgnnklawyqqrpgqaprlliygassrpsgva
drfsgsgsgtdftltisrlepedfavyycqqygqslstfgqgtkvevkrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'N':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2fx8N (N:)
eivltqspgtqslspgeratlscrasqsvgnnklawyqqrpgqaprlliygassrpsgva
drfsgsgsgtdftltisrlepedfavyycqqygqslstfgqgtkvevkrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'O':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2fx8O (O:)
eivltqspgtqslspgeratlscrasqsvgnnklawyqqrpgqaprlliygassrpsgva
drfsgsgsgtdftltisrlepedfavyycqqygqslstfgqgtkvevkrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'P':
    No sequence available.

  • Chain 'Q':
    No sequence available.

  • Chain 'R':
    No sequence available.

  • Chain 'S':
    No sequence available.