PDB entry 2fvl

View 2fvl on RCSB PDB site
Description: Crystal structure of human 3-alpha hydroxysteroid/dihydrodiol dehydrogenase (AKR1C4) complexed with NADP+
Class: Oxidoreductase
Keywords: Chlordecone reductase, aldo-keto reductase, 3alpha-HSD1, DD4, Structural Genomics, Structural Genomics Consortium, SGC, Oxidoreductase
Deposited on 2006-01-31, released 2006-02-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.167
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aldo-keto reductase family 1, member C4
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1C4
    Database cross-references and differences (RAF-indexed):
    • GB AAH20744 (1-323)
    Domains in SCOPe 2.08: d2fvla_
  • Chain 'B':
    Compound: Aldo-keto reductase family 1, member C4
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1C4
    Database cross-references and differences (RAF-indexed):
    • GB AAH20744 (1-323)
    Domains in SCOPe 2.08: d2fvlb_
  • Chain 'C':
    Compound: Aldo-keto reductase family 1, member C4
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1C4
    Database cross-references and differences (RAF-indexed):
    • GB AAH20744 (1-323)
    Domains in SCOPe 2.08: d2fvlc_
  • Heterogens: NAP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2fvlA (A:)
smdpkyqrvelndghfmpvlgfgtyappevprnravevtklaieagfrhidsaylynnee
qvglairskiadgsvkredifytsklwctffqpqmvqpalesslkklqldyvdlyllhfp
malkpgetplpkdengkvifdtvdlsatwevmekckdaglaksigvsnfnyrqlemilnk
pglkykpvcnqvechpylnqsklldfckskdivlvahsalgtqrhklwvdpnspvlledp
vlcalakkhkrtpalialryqlqrgvvvlaksyneqrireniqvfefqltsedmkvldgl
nrnyryvvmdflmdhpdypfsdey

    Sequence, based on observed residues (ATOM records): (download) 
    >2fvlA (A:)
mdpkyqrvelndghfmpvlgfgtyappevprnravevtklaieagfrhidsaylynneeq
vglairskiadgsvkredifytsklwctffqpqmvqpalesslkklqldyvdlyllhfpm
alkpgetplpkdengkvifdtvdlsatwevmekckdaglaksigvsnfnyrqlemilnkp
glkykpvcnqvechpylnqsklldfckskdivlvahsalgtqrhklwvdpnspvlledpv
lcalakkhkrtpalialryqlqrgvvvlaksyneqrireniqvfefqltsedmkvldgln
rnyryvvmdflmdhpdypfsdey

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2fvlB (B:)
smdpkyqrvelndghfmpvlgfgtyappevprnravevtklaieagfrhidsaylynnee
qvglairskiadgsvkredifytsklwctffqpqmvqpalesslkklqldyvdlyllhfp
malkpgetplpkdengkvifdtvdlsatwevmekckdaglaksigvsnfnyrqlemilnk
pglkykpvcnqvechpylnqsklldfckskdivlvahsalgtqrhklwvdpnspvlledp
vlcalakkhkrtpalialryqlqrgvvvlaksyneqrireniqvfefqltsedmkvldgl
nrnyryvvmdflmdhpdypfsdey

    Sequence, based on observed residues (ATOM records): (download) 
    >2fvlB (B:)
mdpkyqrvelndghfmpvlgfgtyappevprnravevtklaieagfrhidsaylynneeq
vglairskiadgsvkredifytsklwctffqpqmvqpalesslkklqldyvdlyllhfpm
alkpgetplpkdengkvifdtvdlsatwevmekckdaglaksigvsnfnyrqlemilnkp
glkykpvcnqvechpylnqsklldfckskdivlvahsalgtqrhklwvdpnspvlledpv
lcalakkhkrtpalialryqlqrgvvvlaksyneqrireniqvfefqltsedmkvldgln
rnyryvvmdflmdhpdypfsdey

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2fvlC (C:)
smdpkyqrvelndghfmpvlgfgtyappevprnravevtklaieagfrhidsaylynnee
qvglairskiadgsvkredifytsklwctffqpqmvqpalesslkklqldyvdlyllhfp
malkpgetplpkdengkvifdtvdlsatwevmekckdaglaksigvsnfnyrqlemilnk
pglkykpvcnqvechpylnqsklldfckskdivlvahsalgtqrhklwvdpnspvlledp
vlcalakkhkrtpalialryqlqrgvvvlaksyneqrireniqvfefqltsedmkvldgl
nrnyryvvmdflmdhpdypfsdey

    Sequence, based on observed residues (ATOM records): (download) 
    >2fvlC (C:)
mdpkyqrvelndghfmpvlgfgtyappevprnravevtklaieagfrhidsaylynneeq
vglairskiadgsvkredifytsklwctffqpqmvqpalesslkklqldyvdlyllhfpm
alkpgetplpkdengkvifdtvdlsatwevmekckdaglaksigvsnfnyrqlemilnkp
glkykpvcnqvechpylnqsklldfckskdivlvahsalgtqrhklwvdpnspvlledpv
lcalakkhkrtpalialryqlqrgvvvlaksyneqrireniqvfefqltsedmkvldgln
rnyryvvmdflmdhpdypfsdey