PDB entry 2fvk

View 2fvk on RCSB PDB site
Description: Crystal structure of dihydropyrimidinase from Saccharomyces kluyveri in complex with the substrate dihydrouracil
Class: Hydrolase
Keywords: beta/alpha barrel, beta sandwich, Hydrolase
Deposited on 2006-01-31, released 2006-03-14
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.181
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydropyrimidinase
    Species: Lachancea kluyveri [TaxId:4934]
    Gene: pyd2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9P903 (0-End)
      • modified residue (165)
    Domains in SCOPe 2.05: d2fvka1, d2fvka2
  • Chain 'B':
    Compound: dihydropyrimidinase
    Species: Lachancea kluyveri [TaxId:4934]
    Gene: pyd2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9P903 (0-End)
      • modified residue (165)
    Domains in SCOPe 2.05: d2fvkb1, d2fvkb2
  • Chain 'C':
    Compound: dihydropyrimidinase
    Species: Lachancea kluyveri [TaxId:4934]
    Gene: pyd2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9P903 (0-End)
      • modified residue (165)
    Domains in SCOPe 2.05: d2fvkc1, d2fvkc2
  • Chain 'D':
    Compound: dihydropyrimidinase
    Species: Lachancea kluyveri [TaxId:4934]
    Gene: pyd2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9P903 (0-540)
      • modified residue (165)
    Domains in SCOPe 2.05: d2fvkd1, d2fvkd2
  • Heterogens: ZN, DUC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2fvkA (A:)
piydliikngiictasdiyaaeiavnngkvqliaasidpslgsevidaegafitpggida
hvhvdeplkllgdvvdtmehatrsavaggtttvvafstqdvskkgpsalaesvkldvdey
seqtlycdyglhlilfqiekpsvearelldvqlqaayndygvssvkmfmtypglqisdyd
imsamyatrkngfttmlhaengdmvkwmiealeeqgltdayyhgvsrpsivegeatnrai
tlattmdtpilfvhvsspqaaevikqaqtkglkvyaetcpqyallsdaitrchhhgeves
ygvgidlssisespftnpddrfigskyicsppirpegtqksiwkgmnngtftivgsdhcs
ynyyektstaskhrafdpennkngefryipnglpgvctrmpllydygylrgnltsmmklv
eiqctnpakvygmypqkgsilpgvsdadlviwypddskkeynskpklitnklmehncdyt
pfegieiknwprytivkgkivykegeilkenadgkylkrgksfmctpknewvtewrpkye
spgddddkhhhhhhhhsgd

    Sequence, based on observed residues (ATOM records): (download) 
    >2fvkA (A:)
piydliikngiictasdiyaaeiavnngkvqliaasidpslgsevidaegafitpggida
hvhvdeplkllgdvvdtmehatrsavaggtttvvafstqdvskkgpsalaesvkldvdey
seqtlycdyglhlilfqiekpsvearelldvqlqaayndygvssvkmfmtypglqisdyd
imsamyatrkngfttmlhaengdmvkwmiealeeqgltdayyhgvsrpsivegeatnrai
tlattmdtpilfvhvsspqaaevikqaqtkglkvyaetcpqyallsdaitrchgvgidls
sisespftnpddrfigskyicsppirpegtqksiwkgmnngtftivgsdhcsynyyekts
taskhrafdpennkngefryipnglpgvctrmpllydygylrgnltsmmklveiqctnpa
kvygmypqkgsilpgvsdadlviwypddskkeynskpklitnklmehncdytpfegieik
nwprytivkgkivykegeilkenadgkylkrgksfmctpknewvtewrpkye

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2fvkB (B:)
piydliikngiictasdiyaaeiavnngkvqliaasidpslgsevidaegafitpggida
hvhvdeplkllgdvvdtmehatrsavaggtttvvafstqdvskkgpsalaesvkldvdey
seqtlycdyglhlilfqiekpsvearelldvqlqaayndygvssvkmfmtypglqisdyd
imsamyatrkngfttmlhaengdmvkwmiealeeqgltdayyhgvsrpsivegeatnrai
tlattmdtpilfvhvsspqaaevikqaqtkglkvyaetcpqyallsdaitrchhhgeves
ygvgidlssisespftnpddrfigskyicsppirpegtqksiwkgmnngtftivgsdhcs
ynyyektstaskhrafdpennkngefryipnglpgvctrmpllydygylrgnltsmmklv
eiqctnpakvygmypqkgsilpgvsdadlviwypddskkeynskpklitnklmehncdyt
pfegieiknwprytivkgkivykegeilkenadgkylkrgksfmctpknewvtewrpkye
spgddddkhhhhhhhhsgd

    Sequence, based on observed residues (ATOM records): (download) 
    >2fvkB (B:)
piydliikngiictasdiyaaeiavnngkvqliaasidpslgsevidaegafitpggida
hvhvdeplkllgdvvdtmehatrsavaggtttvvafstqdvskkgpsalaesvkldvdey
seqtlycdyglhlilfqiekpsvearelldvqlqaayndygvssvkmfmtypglqisdyd
imsamyatrkngfttmlhaengdmvkwmiealeeqgltdayyhgvsrpsivegeatnrai
tlattmdtpilfvhvsspqaaevikqaqtkglkvyaetcpqyallsdaitrchgvgidls
sisespftnpddrfigskyicsppirpegtqksiwkgmnngtftivgsdhcsynyyekts
taskhrafdpennkngefryipnglpgvctrmpllydygylrgnltsmmklveiqctnpa
kvygmypqkgsilpgvsdadlviwypddskkeynskpklitnklmehncdytpfegieik
nwprytivkgkivykegeilkenadgkylkrgksfmctpknewvtewrpkye

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2fvkC (C:)
piydliikngiictasdiyaaeiavnngkvqliaasidpslgsevidaegafitpggida
hvhvdeplkllgdvvdtmehatrsavaggtttvvafstqdvskkgpsalaesvkldvdey
seqtlycdyglhlilfqiekpsvearelldvqlqaayndygvssvkmfmtypglqisdyd
imsamyatrkngfttmlhaengdmvkwmiealeeqgltdayyhgvsrpsivegeatnrai
tlattmdtpilfvhvsspqaaevikqaqtkglkvyaetcpqyallsdaitrchhhgeves
ygvgidlssisespftnpddrfigskyicsppirpegtqksiwkgmnngtftivgsdhcs
ynyyektstaskhrafdpennkngefryipnglpgvctrmpllydygylrgnltsmmklv
eiqctnpakvygmypqkgsilpgvsdadlviwypddskkeynskpklitnklmehncdyt
pfegieiknwprytivkgkivykegeilkenadgkylkrgksfmctpknewvtewrpkye
spgddddkhhhhhhhhsgd

    Sequence, based on observed residues (ATOM records): (download) 
    >2fvkC (C:)
piydliikngiictasdiyaaeiavnngkvqliaasidpslgsevidaegafitpggida
hvhvdeplkllgdvvdtmehatrsavaggtttvvafstqdvskkgpsalaesvkldvdey
seqtlycdyglhlilfqiekpsvearelldvqlqaayndygvssvkmfmtypglqisdyd
imsamyatrkngfttmlhaengdmvkwmiealeeqgltdayyhgvsrpsivegeatnrai
tlattmdtpilfvhvsspqaaevikqaqtkglkvyaetcpqyallsdaitrcgvgidlss
isespftnpddrfigskyicsppirpegtqksiwkgmnngtftivgsdhcsynyyektst
askhrafdpennkngefryipnglpgvctrmpllydygylrgnltsmmklveiqctnpak
vygmypqkgsilpgvsdadlviwypddskkeynskpklitnklmehncdytpfegieikn
wprytivkgkivykegeilkenadgkylkrgksfmctpknewvtewrpkye

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2fvkD (D:)
piydliikngiictasdiyaaeiavnngkvqliaasidpslgsevidaegafitpggida
hvhvdeplkllgdvvdtmehatrsavaggtttvvafstqdvskkgpsalaesvkldvdey
seqtlycdyglhlilfqiekpsvearelldvqlqaayndygvssvkmfmtypglqisdyd
imsamyatrkngfttmlhaengdmvkwmiealeeqgltdayyhgvsrpsivegeatnrai
tlattmdtpilfvhvsspqaaevikqaqtkglkvyaetcpqyallsdaitrchhhgeves
ygvgidlssisespftnpddrfigskyicsppirpegtqksiwkgmnngtftivgsdhcs
ynyyektstaskhrafdpennkngefryipnglpgvctrmpllydygylrgnltsmmklv
eiqctnpakvygmypqkgsilpgvsdadlviwypddskkeynskpklitnklmehncdyt
pfegieiknwprytivkgkivykegeilkenadgkylkrgksfmctpknewvtewrpkye
spgddddkhhhhhhhhsgd

    Sequence, based on observed residues (ATOM records): (download) 
    >2fvkD (D:)
piydliikngiictasdiyaaeiavnngkvqliaasidpslgsevidaegafitpggida
hvhvdeplkllgdvvdtmehatrsavaggtttvvafstqdvskkgpsalaesvkldvdey
seqtlycdyglhlilfqiekpsvearelldvqlqaayndygvssvkmfmtypglqisdyd
imsamyatrkngfttmlhaengdmvkwmiealeeqgltdayyhgvsrpsivegeatnrai
tlattmdtpilfvhvsspqaaevikqaqtkglkvyaetcpqyallsdaitrchvgidlss
isespftnpddrfigskyicsppirpegtqksiwkgmnngtftivgsdhcsynyyektst
askhrafdpennkngefryipnglpgvctrmpllydygylrgnltsmmklveiqctnpak
vygmypqkgsilpgvsdadlviwypddskkeynskpklitnklmehncdytpfegieikn
wprytivkgkivykegeilkenadgkylkrgksfmctpknewvtewrpkyes