PDB entry 2fus

View 2fus on RCSB PDB site
Description: mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid binding site
Class: hydrolyase
Keywords: hydrolyase, carbon oxygen lyase, kreb's cycle enzyme, fumarate hydratase
Deposited on 1997-01-09, released 1997-07-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.178
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fumarase c
    Species: ESCHERICHIA COLI [TaxId:562]
    Gene: FUMC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05042
      • engineered (128)
    Domains in SCOPe 2.08: d2fusa_
  • Chain 'B':
    Compound: fumarase c
    Species: ESCHERICHIA COLI [TaxId:562]
    Gene: FUMC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05042 (0-End)
      • engineered (128)
    Domains in SCOPe 2.08: d2fusb_
  • Heterogens: CIT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2fusA (A:)
mntvrsekdsmgaidvpadklwgaqtqrslehfristekmptslihalaltkraaakvne
dlgllseekasairqaadevlagqhddefplaiwqtgsgtqsnmnmnevlanrasellgg
vrgmerkvnpnddvnksqssndvfptamhvaallalrkqlipqlktltqtlneksrafad
ivkigrthlqdatpltlgqeisgwvamlehnlkhieyslphvaelalggtavgtglnthp
eyarrvadelavitcapfvtapnkfealatcdalvqahgalkglaaslmkiandvrwlas
gprcgigeisipenepgssimpgkvnptqcealtmlccqvmgndvainmggasgnfelnv
frpmvihnflqsvrlladgmesfnkhcavgiepnrerinqllneslmlvtalnthigydk
aaeiakkahkegltlkaaalalgylseaefdswvrpeqmvgsmkagr

    Sequence, based on observed residues (ATOM records): (download) 
    >2fusA (A:)
vrsekdsmgaidvpadklwgaqtqrslehfristekmptslihalaltkraaakvnedlg
llseekasairqaadevlagqhddefplaiwqtgsgtqsnmnmnevlanrasellggvrg
merkvnpnddvnksqssndvfptamhvaallalrkqlipqlktltqtlneksrafadivk
igrthlqdatpltlgqeisgwvamlehnlkhieyslphvaelalggtavgtglnthpeya
rrvadelavitcapfvtapnkfealatcdalvqahgalkglaaslmkiandvrwlasgpr
cgigeisipenepgssimpgkvnptqcealtmlccqvmgndvainmggasgnfelnvfrp
mvihnflqsvrlladgmesfnkhcavgiepnrerinqllneslmlvtalnthigydkaae
iakkahkegltlkaaalalgylseaefdswvrpeqm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2fusB (B:)
mntvrsekdsmgaidvpadklwgaqtqrslehfristekmptslihalaltkraaakvne
dlgllseekasairqaadevlagqhddefplaiwqtgsgtqsnmnmnevlanrasellgg
vrgmerkvnpnddvnksqssndvfptamhvaallalrkqlipqlktltqtlneksrafad
ivkigrthlqdatpltlgqeisgwvamlehnlkhieyslphvaelalggtavgtglnthp
eyarrvadelavitcapfvtapnkfealatcdalvqahgalkglaaslmkiandvrwlas
gprcgigeisipenepgssimpgkvnptqcealtmlccqvmgndvainmggasgnfelnv
frpmvihnflqsvrlladgmesfnkhcavgiepnrerinqllneslmlvtalnthigydk
aaeiakkahkegltlkaaalalgylseaefdswvrpeqmvgsmkagr

    Sequence, based on observed residues (ATOM records): (download) 
    >2fusB (B:)
mntvrsekdsmgaidvpadklwgaqtqrslehfristekmptslihalaltkraaakvne
dlgllseekasairqaadevlagqhddefplaiwqtgsgtqsnmnmnevlanrasellgg
vrgmerkvnpnddvnksqssndvfptamhvaallalrkqlipqlktltqtlneksrafad
ivkigrthlqdatpltlgqeisgwvamlehnlkhieyslphvaelalggtavgtglnthp
eyarrvadelavitcapfvtapnkfealatcdalvqahgalkglaaslmkiandvrwlas
gprcgigeisipenepmpgkvnptqcealtmlccqvmgndvainmggasgnfelnvfrpm
vihnflqsvrlladgmesfnkhcavgiepnrerinqllneslmlvtalnthigydkaaei
akkahkegltlkaaalalgylseaefdswvrpeqm