PDB entry 2fpt

View 2fpt on RCSB PDB site
Description: Dual Binding Mode of a Novel Series of DHODH inhibitors
Class: oxidoreductase
Keywords: protein inhibitor complex, OXIDOREDUCTASE
Deposited on 2006-01-17, released 2007-01-23
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.175
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DHODH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2fpta_
  • Heterogens: SO4, ACT, FMN, ORO, ILB, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2fptA (A:)
    mghhhhhhhhhhssghiddddkhmledpmatgderfyaehlmptlqglldpesahrlavr
    ftslgllprarfqdsdmlevrvlghkfrnpvgiaagfdkhgeavdglykmgfgfveigsv
    tpkpqegnprprvfrlpedqavinrygfnshglsvvehrlrarqqkqakltedglplgvn
    lgknktsvdaaedyaegvrvlgpladylvvnvsspntaglrslqgkaelrrlltkvlqer
    dglrrvhrpavlvkiapdltsqdkediasvvkelgidglivtnttvsrpaglqgalrset
    gglsgkplrdlstqtiremyaltqgrvpiigvggvssgqdalekiragaslvqlytaltf
    wgppvvgkvkreleallkeqgfggvtdaigadhrr
    

    Sequence, based on observed residues (ATOM records): (download)
    >2fptA (A:)
    matgderfyaehlmptlqglldpesahrlavrftslgllpfqdsdmlevrvlghkfrnpv
    giaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnsh
    glsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvn
    vsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvv
    kelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiig
    vggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaiga
    dhrr