PDB entry 2fpt

View 2fpt on RCSB PDB site
Description: Dual Binding Mode of a Novel Series of DHODH inhibitors
Class: oxidoreductase
Keywords: protein inhibitor complex, OXIDOREDUCTASE
Deposited on 2006-01-17, released 2007-01-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-24, with a file datestamp of 2019-07-19.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DHODH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2fpta_
  • Heterogens: SO4, ACT, FMN, ORO, ILB, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2fptA (A:)
mghhhhhhhhhhssghiddddkhmledpmatgderfyaehlmptlqglldpesahrlavr
ftslgllprarfqdsdmlevrvlghkfrnpvgiaagfdkhgeavdglykmgfgfveigsv
tpkpqegnprprvfrlpedqavinrygfnshglsvvehrlrarqqkqakltedglplgvn
lgknktsvdaaedyaegvrvlgpladylvvnvsspntaglrslqgkaelrrlltkvlqer
dglrrvhrpavlvkiapdltsqdkediasvvkelgidglivtnttvsrpaglqgalrset
gglsgkplrdlstqtiremyaltqgrvpiigvggvssgqdalekiragaslvqlytaltf
wgppvvgkvkreleallkeqgfggvtdaigadhrr

    Sequence, based on observed residues (ATOM records): (download) 
    >2fptA (A:)
matgderfyaehlmptlqglldpesahrlavrftslgllpfqdsdmlevrvlghkfrnpv
giaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnsh
glsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvn
vsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvv
kelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiig
vggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaiga
dhrr