PDB entry 2fme

View 2fme on RCSB PDB site
Description: Crystal structure of the mitotic kinesin eg5 (ksp) in complex with mg-adp and (r)-4-(3-hydroxyphenyl)-n,n,7,8-tetramethyl-3,4-dihydroisoquinoline-2(1h)-carboxamide
Class: cell cycle
Keywords: Eg5 KSP Mg-ADP Complex Inhibitor
Deposited on 2006-01-09, released 2006-04-18
The last revision prior to the SCOP 1.75 freeze date was dated 2006-05-30, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.28
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Kinesin-like protein KIF11
    Species: HOMO SAPIENS
    Gene: KIF11, EG5, KNSL1
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2fmea1
  • Chain 'B':
    Compound: Kinesin-like protein KIF11
    Species: HOMO SAPIENS
    Gene: KIF11, EG5, KNSL1
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2fmeb1
  • Heterogens: MG, 3QC, ADP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2fmeA (A:)
masqpnssakkkeekgkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladk
ssrktytfdmvfgastkqidvyrsvvcpildevimgynctifaygqtgtgktftmegers
pneeytweedplagiiprtlhqifekltdngtefsvkvslleiyneelfdllnpssdvse
rlqmfddprnkrgviikgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfs
vtihmkettidgeelvkigklnlvdlagsenigrsgavdkrareagninqslltlgrvit
alvertphvpyreskltrilqdslggrtrtsiiatispaslnleetlstleyahraknil
nkpevnqk

    Sequence, based on observed residues (ATOM records): (download) 
    >2fmeA (A:)
kniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggssrktytfdmvfgastkqid
vyrsvvcpildevimgynctifaygqtgtgktftmegerspneeytweedplagiiprtl
hqifekltdngtefsvkvslleiyneelfdllnpssdvserlqmfddprnkrgviikgle
eitvhnkdevyqilekgaakrttaatlmnayssrshsvfsvtihmkvkigklnlvdlags
enigrinqslltlgrvitalvertphvpyreskltrilqdslggrtrtsiiatispasln
leetlstleyahraknilnkp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2fmeB (B:)
masqpnssakkkeekgkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladk
ssrktytfdmvfgastkqidvyrsvvcpildevimgynctifaygqtgtgktftmegers
pneeytweedplagiiprtlhqifekltdngtefsvkvslleiyneelfdllnpssdvse
rlqmfddprnkrgviikgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfs
vtihmkettidgeelvkigklnlvdlagsenigrsgavdkrareagninqslltlgrvit
alvertphvpyreskltrilqdslggrtrtsiiatispaslnleetlstleyahraknil
nkpevnqk

    Sequence, based on observed residues (ATOM records): (download) 
    >2fmeB (B:)
kniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggssrktytfdmvfgastkqid
vyrsvvcpildevimgynctifaygqtgtgktftmegerspneeytweedplagiiprtl
hqifekltdngtefsvkvslleiyneelfdllnpssdvserlqmfddprnkrgviikgle
eitvhnkdevyqilekgaakrttaatlmnayssrshsvfsvtihmkettidgeelvkigk
lnlvdlagsenigrinqslltlgrvitalvertphvpyreskltrilqdslggrtrtsii
atispaslnleetlstleyahraknilnk