PDB entry 2flr

View 2flr on RCSB PDB site
Description: Novel 5-Azaindole Factor VIIa Inhibitors
Class: hydrolase/blood clotting
Keywords: short hydrogen bond, 5-Azaindole inhibitors, S1 site, HYDROLASE-BLOOD CLOTTING COMPLEX
Deposited on 2006-01-06, released 2007-01-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-18, with a file datestamp of 2017-10-13.
Experiment type: XRAY
Resolution: 2.3499999999999996 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Coagulation factor VII
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2flrh_
  • Chain 'L':
    Compound: Coagulation factor VII
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2flrl1, d2flrl2
  • Chain 'T':
    Compound: tissue factor
    Species: Homo sapiens [TaxId:9606]
    Gene: F3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2flrt1, d2flrt2
  • Heterogens: 7NH, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2flrH (H:)
    ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
    lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
    lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
    sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
    seprpgvllrapfp
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >2flrL (L:)
    anafleelrpgslereckeeqcsfeeareifkdaertklfwisysdgdqcasspcqnggs
    ckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgtkrscrchegysl
    ladgvsctptveypcgkipilekrnaskpqgr
    

    Sequence, based on observed residues (ATOM records): (download)
    >2flrL (L:)
    gdqcasspcqnggsckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdht
    gtkrscrchegyslladgvsctptveypcgkipile
    

  • Chain 'T':
    Sequence, based on SEQRES records: (download)
    >2flrT (T:)
    gttntvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltd
    eivkdvkqtylarvfsypagnvestgsageplyenspeftpyletnlgqptiqsfeqvgt
    kvnvtvedertlvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvdk
    genycfsvqavipsrtvnrkstdspvecmgqekgefre
    

    Sequence, based on observed residues (ATOM records): (download)
    >2flrT (T:)
    tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
    dvkqtylarvfsypagnvestgsageplyenspeftpyletnlgdertlvrrnntflslr
    dvfgkdliytlyysvqavipsrtvnrkstds