PDB entry 2flb

View 2flb on RCSB PDB site
Description: Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor
Class: hydrolase/blood clotting
Keywords: active site-directed, short hydrogen bond-mediated, pyrazole-based inhibitor, HYDROLASE/BLOOD CLOTTING COMPLEX
Deposited on 2006-01-05, released 2006-04-04
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.247
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Coagulation factor VII
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2flbh_
  • Chain 'L':
    Compound: Coagulation factor VII
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed):
  • Chain 'T':
    Compound: tissue factor
    Species: Homo sapiens [TaxId:9606]
    Gene: F3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2flbt1, d2flbt2
  • Heterogens: 6NH, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2flbH (H:)
    ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
    lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
    lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
    sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
    seprpgvllrapfp
    

  • Chain 'L':
    No sequence available.

  • Chain 'T':
    Sequence, based on SEQRES records: (download)
    >2flbT (T:)
    gttntvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltd
    eivkdvkqtylarvfsypagnvestgsageplyenspeftpyletnlgqptiqsfeqvgt
    kvnvtvedertlvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvdk
    genycfsvqavipsrtvnrkstdspvecmgqekgefre
    

    Sequence, based on observed residues (ATOM records): (download)
    >2flbT (T:)
    tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
    dvkqtylarvfsypagnvestgsageplyenspeftpyletnlgdertlvrrnntflslr
    dvfgkdliytlyysvqavipsrtvnrkstds