PDB entry 2flb

View 2flb on RCSB PDB site
Description: Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor
Class: hydrolase/blood clotting
Keywords: active site-directed, short hydrogen bond-mediated, pyrazole-based inhibitor
Deposited on 2006-01-05, released 2006-04-04
The last revision prior to the SCOP 1.75 freeze date was dated 2006-04-18, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.247
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Coagulation factor VII
    Species: HOMO SAPIENS
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2flbh1
  • Chain 'L':
    Compound: Coagulation factor VII
    Species: HOMO SAPIENS
    Gene: F7
    Database cross-references and differences (RAF-indexed):
  • Chain 'T':
    Compound: tissue factor
    Species: HOMO SAPIENS
    Gene: F3
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2flbt1, d2flbt2
  • Heterogens: 6NH, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2flbH (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

  • Chain 'L':
    No sequence available.

  • Chain 'T':
    Sequence, based on SEQRES records: (download) 
    >2flbT (T:)
gttntvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltd
eivkdvkqtylarvfsypagnvestgsageplyenspeftpyletnlgqptiqsfeqvgt
kvnvtvedertlvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvdk
genycfsvqavipsrtvnrkstdspvecmgqekgefre

    Sequence, based on observed residues (ATOM records): (download) 
    >2flbT (T:)
tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
dvkqtylarvfsypagnvestgsageplyenspeftpyletnlgdertlvrrnntflslr
dvfgkdliytlyysvqavipsrtvnrkstds