PDB entry 2fjh

View 2fjh on RCSB PDB site
Description: Structure of the B20-4 Fab, a phage derived Fab fragment, in complex with VEGF
Class: hormone/growth factor/immune system
Keywords: VEGF, Fab, Protein Fab complex, Cystine knot, HORMONE-GROWTH FACTOR-IMMUNE SYSTEM COMPLEX
Deposited on 2006-01-02, released 2006-02-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.2
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fab fragment light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2FJH (0-End)
    Domains in SCOPe 2.08: d2fjha1, d2fjha2
  • Chain 'B':
    Compound: Fab fragment heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2FJH (0-End)
    Domains in SCOPe 2.08: d2fjhb_
  • Chain 'H':
    Compound: Fab fragment heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2FJH (0-End)
    Domains in SCOPe 2.08: d2fjhh_
  • Chain 'L':
    Compound: Fab fragment light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2FJH (0-213)
    Domains in SCOPe 2.08: d2fjhl1, d2fjhl2
  • Chain 'V':
    Compound: Vascular Endothelial Growth Factor A
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2fjhv_
  • Chain 'W':
    Compound: Vascular Endothelial Growth Factor A
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2fjhw_

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2fjhA (A:)
diqmtqspsslsasvgdrvtitcrasqvirrslawyqqkpgkapklliyaasnlasgvps
rfsgsgsgtdftltisslqpedfatyycqqsntspltfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >2fjhA (A:)
diqmtqspsslsasvgdrvtitcrasqvirrslawyqqkpgkapklliyaasnlasgvps
rfsgsgsgtdftltisslqpedfatyycqqsntspltfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2fjhB (B:)
evqlvesggglvqpggslrlscaasgftinaswihwvrqapgkglewvgaiypysgytny
adsvkgrftisadtskntaylqmnslraedtavyycarwghstspwamdywgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkth

    Sequence, based on observed residues (ATOM records): (download) 
    >2fjhB (B:)
evqlvesggglvqpggslrlscaasgftinaswihwvrqapgkglewvgaiypysgytny
adsvkgrftisadtskntaylqmnslraedtavyycarwghstspwamdywgqgtlvtvs
sastkgpsvfplapssgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >2fjhH (H:)
evqlvesggglvqpggslrlscaasgftinaswihwvrqapgkglewvgaiypysgytny
adsvkgrftisadtskntaylqmnslraedtavyycarwghstspwamdywgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkth

    Sequence, based on observed residues (ATOM records): (download) 
    >2fjhH (H:)
evqlvesggglvqpggslrlscaasgftinaswihwvrqapgkglewvgaiypysgytny
adsvkgrftisadtskntaylqmnslraedtavyycarwghstspwamdywgqgtlvtvs
sastkgpsvfplapssgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2fjhL (L:)
diqmtqspsslsasvgdrvtitcrasqvirrslawyqqkpgkapklliyaasnlasgvps
rfsgsgsgtdftltisslqpedfatyycqqsntspltfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

  • Chain 'V':
    Sequence, based on SEQRES records: (download) 
    >2fjhV (V:)
gqnhhevvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndegle
cvpteesnitmqimrikphqgqhigemsflqhnkcecrpkkd

    Sequence, based on observed residues (ATOM records): (download) 
    >2fjhV (V:)
hevvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndeglecvpt
eesnitmqimrikphqgqhigemsflqhnkcecrpkkd

  • Chain 'W':
    Sequence, based on SEQRES records: (download) 
    >2fjhW (W:)
gqnhhevvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndegle
cvpteesnitmqimrikphqgqhigemsflqhnkcecrpkkd

    Sequence, based on observed residues (ATOM records): (download) 
    >2fjhW (W:)
evvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndeglecvpte
esnitmqimrikphqgqhigemsflqhnkcecrpkkd