PDB entry 2fjg

View 2fjg on RCSB PDB site
Description: Structure of the G6 Fab, a phage derived Fab fragment, in complex with VEGF
Class: hormone/growth factor/immune system
Keywords: Protein Fab Complex, FAB, VEGF, Cystine knot, HORMONE-GROWTH FACTOR-IMMUNE SYSTEM COMPLEX
Deposited on 2006-01-02, released 2006-02-07
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.201
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2FJG (0-End)
    Domains in SCOPe 2.03: d2fjga1, d2fjga2
  • Chain 'B':
    Compound: Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2FJG (0-End)
    Domains in SCOPe 2.03: d2fjgb1, d2fjgb2
  • Chain 'H':
    Compound: Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2FJG (0-End)
    Domains in SCOPe 2.03: d2fjgh1, d2fjgh2
  • Chain 'L':
    Compound: Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2FJG (0-End)
    Domains in SCOPe 2.03: d2fjgl1, d2fjgl2
  • Chain 'V':
    Compound: Vascular Endothelial Growth Factor A
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2fjgv_
  • Chain 'W':
    Compound: Vascular Endothelial Growth Factor A
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2fjgw_
  • Heterogens: SO4

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2fjgA (A:)
    diqmtqspsslsasvgdrvtitcrasqdvstavawyqqkpgkapklliysasflysgvps
    rfsgsgsgtdftltisslqpedfatyycqqsyttpptfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

    Sequence, based on observed residues (ATOM records): (download)
    >2fjgA (A:)
    diqmtqspsslsasvgdrvtitcrasqdvstavawyqqkpgkapklliysasflysgvps
    rfsgsgsgtdftltisslqpedfatyycqqsyttpptfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnr
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2fjgB (B:)
    evqlvesggglvqpggslrlscaasgftisdywihwvrqapgkglewvagitpaggytyy
    adsvkgrftisadtskntaylqmnslraedtavyycarfvfflpyamdywgqgtlvtvss
    astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
    glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkth
    

    Sequence, based on observed residues (ATOM records): (download)
    >2fjgB (B:)
    evqlvesggglvqpggslrlscaasgftisdywihwvrqapgkglewvagitpaggytyy
    adsvkgrftisadtskntaylqmnslraedtavyycarfvfflpyamdywgqgtlvtvss
    astkgpsvfplapssgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysl
    ssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >2fjgH (H:)
    evqlvesggglvqpggslrlscaasgftisdywihwvrqapgkglewvagitpaggytyy
    adsvkgrftisadtskntaylqmnslraedtavyycarfvfflpyamdywgqgtlvtvss
    astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
    glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkth
    

    Sequence, based on observed residues (ATOM records): (download)
    >2fjgH (H:)
    evqlvesggglvqpggslrlscaasgftisdywihwvrqapgkglewvagitpaggytyy
    adsvkgrftisadtskntaylqmnslraedtavyycarfvfflpyamdywgqgtlvtvss
    astkgpsvfplapssgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysl
    ssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >2fjgL (L:)
    diqmtqspsslsasvgdrvtitcrasqdvstavawyqqkpgkapklliysasflysgvps
    rfsgsgsgtdftltisslqpedfatyycqqsyttpptfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

    Sequence, based on observed residues (ATOM records): (download)
    >2fjgL (L:)
    diqmtqspsslsasvgdrvtitcrasqdvstavawyqqkpgkapklliysasflysgvps
    rfsgsgsgtdftltisslqpedfatyycqqsyttpptfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnr
    

  • Chain 'V':
    Sequence, based on SEQRES records: (download)
    >2fjgV (V:)
    gqnhhevvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndegle
    cvpteesnitmqimrikphqgqhigemsflqhnkcecrpkkd
    

    Sequence, based on observed residues (ATOM records): (download)
    >2fjgV (V:)
    vvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndeglecvptee
    snitmqimrikphqgqhigemsflqhnkcecrpkk
    

  • Chain 'W':
    Sequence, based on SEQRES records: (download)
    >2fjgW (W:)
    gqnhhevvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndegle
    cvpteesnitmqimrikphqgqhigemsflqhnkcecrpkkd
    

    Sequence, based on observed residues (ATOM records): (download)
    >2fjgW (W:)
    vvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndeglecvptee
    snitmqimrikphqgqhigemsflqhnkcecrpk