PDB entry 2fir

View 2fir on RCSB PDB site
Description: Crystal structure of DFPR-VIIa/sTF
Class: blood clotting
Keywords: Factor VIIa, soluble tissue factor, sodium, magnesium, zinc, oxyanion hole, serine protease, blood coagulation
Deposited on 2005-12-30, released 2006-07-11
The last revision prior to the SCOP 1.73 freeze date was dated 2006-09-05, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.207
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: Peptide (INHIBITOR)
  • Chain 'H':
    Compound: Coagulation factor VII Heavy Chain (EC 3.4.21.21)
    Species: HOMO SAPIENS
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2firh1
  • Chain 'L':
    Compound: Coagulation factor VII light chain
    Species: HOMO SAPIENS
    Gene: F7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08709 (0-141)
      • modified residue (5-6)
      • modified residue (13)
      • modified residue (15)
      • modified residue (18-19)
      • modified residue (24-25)
      • modified residue (28)
      • modified residue (34)
    Domains in SCOP 1.73: d2firl1, d2firl2, d2firl3
  • Chain 'T':
    Compound: tissue factor
    Species: HOMO SAPIENS
    Gene: F3
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2firt1, d2firt2
  • Heterogens: GLC, FUC, MG, CA, NA, ZN, CL, HOH

PDB Chain Sequences:

  • Chain 'C':
    No sequence available.

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2firH (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2firL (L:)
anafleelrpgslereckeeqcsfeeareifkdaertklfwisysdgdqcasspcqnggs
ckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgtkrscrchegysl
ladgvsctptveypcgkipile

  • Chain 'T':
    Sequence, based on SEQRES records: (download) 
    >2firT (T:)
tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
dvkqtylarvfsypagnvestgsageplyenspeftpyletnlgqptiqsfeqvgtkvnv
tvedertlvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvdkgeny
cfsvqavipsrtvnrkstdspvecm

    Sequence, based on observed residues (ATOM records): (download) 
    >2firT (T:)
tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
dvkqtylarvfsypagngeplyenspeftpyletnlgqptiqsfeqvgtkvnvtvedert
lvrrnntflslrdvfgkdliytlyywktaktntneflidvdkgenycfsvqavipsrtvn
rkstdspvecm