PDB entry 2fir

View 2fir on RCSB PDB site
Description: Crystal structure of DFPR-VIIa/sTF
Class: hydrolase/hydrolase inhibitor
Keywords: Factor VIIa, soluble tissue factor, oxyanion hole, serine protease, blood coagulation, BLOOD CLOTTING, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2005-12-30, released 2006-07-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Coagulation factor VII Heavy Chain (EC 3.4.21.21)
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2firh_
  • Chain 'L':
    Compound: Coagulation factor VII light chain
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2firl1, d2firl2, d2firl3
  • Chain 'T':
    Compound: tissue factor
    Species: Homo sapiens [TaxId:9606]
    Gene: F3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2firt1, d2firt2
  • Heterogens: GLC, FUC, MG, CA, 0G7, NA, ZN, CL, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2firH (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2firL (L:)
anafleelrpgslereckeeqcsfeeareifkdaertklfwisysdgdqcasspcqnggs
ckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgtkrscrchegysl
ladgvsctptveypcgkipile

  • Chain 'T':
    Sequence, based on SEQRES records: (download) 
    >2firT (T:)
tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
dvkqtylarvfsypagnvestgsageplyenspeftpyletnlgqptiqsfeqvgtkvnv
tvedertlvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvdkgeny
cfsvqavipsrtvnrkstdspvecm

    Sequence, based on observed residues (ATOM records): (download) 
    >2firT (T:)
tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
dvkqtylarvfsypagngeplyenspeftpyletnlgqptiqsfeqvgtkvnvtvedert
lvrrnntflslrdvfgkdliytlyywktaktntneflidvdkgenycfsvqavipsrtvn
rkstdspvecm