PDB entry 2fdw

View 2fdw on RCSB PDB site
Description: Crystal Structure Of Human Microsomal P450 2A6 with the inhibitor (5-(Pyridin-3-yl)furan-2-yl)methanamine bound
Class: oxidoreductase
Keywords: cyp2a6, p450 2a6, p450, monooxygenase, drug metabolizing enzyme, coumarin 7-hydroxylase, nicotine oxidase, oxidoreductase
Deposited on 2005-12-14, released 2006-11-28
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.205
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytochrome P450 2A6
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP2A6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2fdwa_
  • Chain 'B':
    Compound: Cytochrome P450 2A6
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP2A6
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11509 (Start-471)
      • expression tag (472-473)
    Domains in SCOPe 2.03: d2fdwb_
  • Chain 'C':
    Compound: Cytochrome P450 2A6
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP2A6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2fdwc_
  • Chain 'D':
    Compound: Cytochrome P450 2A6
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP2A6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2fdwd_
  • Heterogens: HEM, D3G, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2fdwA (A:)
makktsskgklppgptplpfignylqlnteqmynslmkiserygpvftihlgprrvvvlc
ghdavrealvdqaeefsgrgeqatfdwvfkgygvvfsngerakqlrrfsiatlrdfgvgk
rgieeriqeeagflidalrgtgganidptfflsrtvsnvissivfgdrfdykdkeflsll
rmmlgifqftststgqlyemfssvmkhlpgpqqqafqllqgledfiakkvehnqrtldpn
sprdfidsflirmqeeeknpntefylknlvmttlnlfiggtetvsttlrygflllmkhpe
veakvheeidrvigknrqpkfedrakmpymeaviheiqrfgdvipmslarrvkkdtkfrd
fflpkgtevypmlgsvlrdpsffsnpqdfnpqhflnekgqfkksdafvpfsigkrncfge
glarmelflffttvmqnfrlkssqspkdidvspkhvgfatiprnytmsflprhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2fdwA (A:)
kgklppgptplpfignylqlnteqmynslmkiserygpvftihlgprrvvvlcghdavre
alvdqaeefsgrgeqatfdwvfkgygvvfsngerakqlrrfsiatlrdfgvgkrgieeri
qeeagflidalrgtgganidptfflsrtvsnvissivfgdrfdykdkeflsllrmmlgif
qftststgqlyemfssvmkhlpgpqqqafqllqgledfiakkvehnqrtldpnsprdfid
sflirmqeeeknpntefylknlvmttlnlfiggtetvsttlrygflllmkhpeveakvhe
eidrvigknrqpkfedrakmpymeaviheiqrfgdvipmslarrvkkdtkfrdfflpkgt
evypmlgsvlrdpsffsnpqdfnpqhflnekgqfkksdafvpfsigkrncfgeglarmel
flffttvmqnfrlkssqspkdidvspkhvgfatiprnytmsflpr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2fdwB (B:)
makktsskgklppgptplpfignylqlnteqmynslmkiserygpvftihlgprrvvvlc
ghdavrealvdqaeefsgrgeqatfdwvfkgygvvfsngerakqlrrfsiatlrdfgvgk
rgieeriqeeagflidalrgtgganidptfflsrtvsnvissivfgdrfdykdkeflsll
rmmlgifqftststgqlyemfssvmkhlpgpqqqafqllqgledfiakkvehnqrtldpn
sprdfidsflirmqeeeknpntefylknlvmttlnlfiggtetvsttlrygflllmkhpe
veakvheeidrvigknrqpkfedrakmpymeaviheiqrfgdvipmslarrvkkdtkfrd
fflpkgtevypmlgsvlrdpsffsnpqdfnpqhflnekgqfkksdafvpfsigkrncfge
glarmelflffttvmqnfrlkssqspkdidvspkhvgfatiprnytmsflprhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2fdwB (B:)
klppgptplpfignylqlnteqmynslmkiserygpvftihlgprrvvvlcghdavreal
vdqaeefsgrgeqatfdwvfkgygvvfsngerakqlrrfsiatlrdfgvgkrgieeriqe
eagflidalrgtgganidptfflsrtvsnvissivfgdrfdykdkeflsllrmmlgifqf
tststgqlyemfssvmkhlpgpqqqafqllqgledfiakkvehnqrtldpnsprdfidsf
lirmqeeeknpntefylknlvmttlnlfiggtetvsttlrygflllmkhpeveakvheei
drvigknrqpkfedrakmpymeaviheiqrfgdvipmslarrvkkdtkfrdfflpkgtev
ypmlgsvlrdpsffsnpqdfnpqhflnekgqfkksdafvpfsigkrncfgeglarmelfl
ffttvmqnfrlkssqspkdidvspkhvgfatiprnytmsflprhh

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2fdwC (C:)
makktsskgklppgptplpfignylqlnteqmynslmkiserygpvftihlgprrvvvlc
ghdavrealvdqaeefsgrgeqatfdwvfkgygvvfsngerakqlrrfsiatlrdfgvgk
rgieeriqeeagflidalrgtgganidptfflsrtvsnvissivfgdrfdykdkeflsll
rmmlgifqftststgqlyemfssvmkhlpgpqqqafqllqgledfiakkvehnqrtldpn
sprdfidsflirmqeeeknpntefylknlvmttlnlfiggtetvsttlrygflllmkhpe
veakvheeidrvigknrqpkfedrakmpymeaviheiqrfgdvipmslarrvkkdtkfrd
fflpkgtevypmlgsvlrdpsffsnpqdfnpqhflnekgqfkksdafvpfsigkrncfge
glarmelflffttvmqnfrlkssqspkdidvspkhvgfatiprnytmsflprhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2fdwC (C:)
gklppgptplpfignylqlnteqmynslmkiserygpvftihlgprrvvvlcghdavrea
lvdqaeefsgrgeqatfdwvfkgygvvfsngerakqlrrfsiatlrdfgvgkrgieeriq
eeagflidalrgtgganidptfflsrtvsnvissivfgdrfdykdkeflsllrmmlgifq
ftststgqlyemfssvmkhlpgpqqqafqllqgledfiakkvehnqrtldpnsprdfids
flirmqeeeknpntefylknlvmttlnlfiggtetvsttlrygflllmkhpeveakvhee
idrvigknrqpkfedrakmpymeaviheiqrfgdvipmslarrvkkdtkfrdfflpkgte
vypmlgsvlrdpsffsnpqdfnpqhflnekgqfkksdafvpfsigkrncfgeglarmelf
lffttvmqnfrlkssqspkdidvspkhvgfatiprnytmsflpr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2fdwD (D:)
makktsskgklppgptplpfignylqlnteqmynslmkiserygpvftihlgprrvvvlc
ghdavrealvdqaeefsgrgeqatfdwvfkgygvvfsngerakqlrrfsiatlrdfgvgk
rgieeriqeeagflidalrgtgganidptfflsrtvsnvissivfgdrfdykdkeflsll
rmmlgifqftststgqlyemfssvmkhlpgpqqqafqllqgledfiakkvehnqrtldpn
sprdfidsflirmqeeeknpntefylknlvmttlnlfiggtetvsttlrygflllmkhpe
veakvheeidrvigknrqpkfedrakmpymeaviheiqrfgdvipmslarrvkkdtkfrd
fflpkgtevypmlgsvlrdpsffsnpqdfnpqhflnekgqfkksdafvpfsigkrncfge
glarmelflffttvmqnfrlkssqspkdidvspkhvgfatiprnytmsflprhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2fdwD (D:)
gklppgptplpfignylqlnteqmynslmkiserygpvftihlgprrvvvlcghdavrea
lvdqaeefsgrgeqatfdwvfkgygvvfsngerakqlrrfsiatlrdfgvgkrgieeriq
eeagflidalrgtgganidptfflsrtvsnvissivfgdrfdykdkeflsllrmmlgifq
ftststgqlyemfssvmkhlpgpqqqafqllqgledfiakkvehnqrtldpnsprdfids
flirmqeeeknpntefylknlvmttlnlfiggtetvsttlrygflllmkhpeveakvhee
idrvigknrqpkfedrakmpymeaviheiqrfgdvipmslarrvkkdtkfrdfflpkgte
vypmlgsvlrdpsffsnpqdfnpqhflnekgqfkksdafvpfsigkrncfgeglarmelf
lffttvmqnfrlkssqspkdidvspkhvgfatiprnytmsflpr