PDB entry 2fap

View 2fap on RCSB PDB site
Description: the structure of the immunophilin-immunosuppressant fkbp12-(c16)-ethoxy rapamycin complex interacting with huma
Class: complex (isomerase/kinase)
Keywords: fkbp12, frap, rapamycin, complex (isomerase/kinase)
Deposited on 1998-09-22, released 1999-05-18
The last revision prior to the SCOP 1.75 freeze date was dated 2003-04-01, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.196
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: fk506-binding protein
  Species: HOMO SAPIENS
  Gene: HUMAN HIPPOCAMPAL CDNA LIBRARY (CLONTECH, PALO ALTO, CA)
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62942 (0-106)
  Domains in SCOP 1.75: d2fapa_
• Chain 'B':
  Compound: frap
  Species: HOMO SAPIENS
  Gene: HUMAN HIPPOCAMPAL CDNA LIBRARY
  Database cross-references and differences (RAF-indexed):
  • Uniprot P42345 (0-93)
  Domains in SCOP 1.75: d2fapb_
• Heterogens: RAD, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2fapA (A:)
  gvqvetispgdgrtfpkrgqtcvvhytgmledgkkfdssrdrnkpfkfmlgkqevirgwe
  egvaqmsvgqrakltispdyaygatghpgiipphatlvfdvellkle
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2fapB (B:)
  vailwhemwhegleeasrlyfgernvkgmfevleplhammergpqtlketsfnqaygrdl
  meaqewcrkymksgnvkdltqawdlyyhvfrris