PDB entry 2f9p

View 2f9p on RCSB PDB site
Description: Crystal Structure of the Recombinant Human Alpha I Tryptase Mutant D216G in Complex with Leupeptin
Class: hydrolase/hydrolase inhibitor
Keywords: serine proteinase, leupeptin, trypsin-like, difucosylation, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Deposited on 2005-12-06, released 2006-01-31
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.217
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tryptase alpha-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TPSAB1, TPS1
    Database cross-references and differences (RAF-indexed):
    • GB AAA86934 (0-End)
      • engineered (45)
      • engineered (214)
    Domains in SCOPe 2.06: d2f9pa_
  • Chain 'B':
    Compound: Tryptase alpha-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TPSAB1, TPS1
    Database cross-references and differences (RAF-indexed):
    • GB AAA86934 (0-End)
      • engineered (45)
      • engineered (214)
    Domains in SCOPe 2.06: d2f9pb_
  • Chain 'C':
    Compound: Tryptase alpha-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TPSAB1, TPS1
    Database cross-references and differences (RAF-indexed):
    • GB AAA86934 (0-End)
      • engineered (45)
      • engineered (214)
    Domains in SCOPe 2.06: d2f9pc_
  • Chain 'D':
    Compound: Tryptase alpha-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TPSAB1, TPS1
    Database cross-references and differences (RAF-indexed):
    • GB AAA86934 (0-End)
      • engineered (45)
      • engineered (214)
    Domains in SCOPe 2.06: d2f9pd_
  • Chain 'E':
    Compound: leupeptin
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00487 (Start-2)
  • Chain 'F':
    Compound: leupeptin
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00487 (Start-2)
  • Chain 'G':
    Compound: leupeptin
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00487 (Start-2)
  • Chain 'H':
    Compound: leupeptin
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00487 (Start-2)
  • Heterogens: NAG, BU3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2f9pA (A:)
ivggqeaprskwpwqvslrvrdrywmhfcggslihpqwvltaahcvgpdvkdlatlrvql
reqhlyyqdqllpvsriivhpqfyiiqtgadialleleepvnissrvhtvmlppasetfp
pgmpcwvtgwgdvdndeplpppfplkqvkvpimenhicdakyhlgaytgddvriirddml
cagnsqrdsckgdsggplvckvngtwlqagvvswgegcaqpnrpgiytrvtyyldwihhy
vpkkp

    Sequence, based on observed residues (ATOM records): (download) 
    >2f9pA (A:)
ivggqeaprskwpwqvslrvrdrywmhfcggslihpqwvltaahcvgpdvkdlatlrvql
reqhlyyqdqllpvsriivhpqfyiiqtgadialleleepvnissrvhtvmlppasetfp
pgmpcwvtgwgdvdndeplpppfplkqvkvpimenhicdakyhlgaytgddvriirddml
cagnsqrdsckgdsggplvckvngtwlqagvvswgegcaqpnrpgiytrvtyyldwihhy
vpk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2f9pB (B:)
ivggqeaprskwpwqvslrvrdrywmhfcggslihpqwvltaahcvgpdvkdlatlrvql
reqhlyyqdqllpvsriivhpqfyiiqtgadialleleepvnissrvhtvmlppasetfp
pgmpcwvtgwgdvdndeplpppfplkqvkvpimenhicdakyhlgaytgddvriirddml
cagnsqrdsckgdsggplvckvngtwlqagvvswgegcaqpnrpgiytrvtyyldwihhy
vpkkp

    Sequence, based on observed residues (ATOM records): (download) 
    >2f9pB (B:)
ivggqeaprskwpwqvslrvrdrywmhfcggslihpqwvltaahcvgpdvkdlatlrvql
reqhlyyqdqllpvsriivhpqfyiiqtgadialleleepvnissrvhtvmlppasetfp
pgmpcwvtgwgdvdndeplpppfplkqvkvpimenhicdakyhlgaytgddvriirddml
cagnsqrdsckgdsggplvckvngtwlqagvvswgegcaqpnrpgiytrvtyyldwihhy
vpk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2f9pC (C:)
ivggqeaprskwpwqvslrvrdrywmhfcggslihpqwvltaahcvgpdvkdlatlrvql
reqhlyyqdqllpvsriivhpqfyiiqtgadialleleepvnissrvhtvmlppasetfp
pgmpcwvtgwgdvdndeplpppfplkqvkvpimenhicdakyhlgaytgddvriirddml
cagnsqrdsckgdsggplvckvngtwlqagvvswgegcaqpnrpgiytrvtyyldwihhy
vpkkp

    Sequence, based on observed residues (ATOM records): (download) 
    >2f9pC (C:)
ivggqeaprskwpwqvslrvrdrywmhfcggslihpqwvltaahcvgpdvkdlatlrvql
reqhlyyqdqllpvsriivhpqfyiiqtgadialleleepvnissrvhtvmlppasetfp
pgmpcwvtgwgdvdndeplpppfplkqvkvpimenhicdakyhlgaytgddvriirddml
cagnsqrdsckgdsggplvckvngtwlqagvvswgegcaqpnrpgiytrvtyyldwihhy
vpk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2f9pD (D:)
ivggqeaprskwpwqvslrvrdrywmhfcggslihpqwvltaahcvgpdvkdlatlrvql
reqhlyyqdqllpvsriivhpqfyiiqtgadialleleepvnissrvhtvmlppasetfp
pgmpcwvtgwgdvdndeplpppfplkqvkvpimenhicdakyhlgaytgddvriirddml
cagnsqrdsckgdsggplvckvngtwlqagvvswgegcaqpnrpgiytrvtyyldwihhy
vpkkp

    Sequence, based on observed residues (ATOM records): (download) 
    >2f9pD (D:)
ivggqeaprskwpwqvslrvrdrywmhfcggslihpqwvltaahcvgpdvkdlatlrvql
reqhlyyqdqllpvsriivhpqfyiiqtgadialleleepvnissrvhtvmlppasetfp
pgmpcwvtgwgdvdndeplpppfplkqvkvpimenhicdakyhlgaytgddvriirddml
cagnsqrdsckgdsggplvckvngtwlqagvvswgegcaqpnrpgiytrvtyyldwihhy
vp

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.