PDB entry 2f9n

View 2f9n on RCSB PDB site
Description: Crystal Structure of the Recombinant Human Alpha I Tryptase Mutant K192Q/D216G in Complex with Leupeptin
Class: hydrolase/hydrolase inhibitor
Keywords: serine proteinase, leupeptin, trypsin-like, difucosylation, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2005-12-06, released 2006-01-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: alpha I tryptase
    Species: Homo sapiens [TaxId:9606]
    Gene: TPS1, TPS2, TPSAB1, TPSB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15157 (0-End)
      • engineered (45)
      • variant (184-185)
      • engineered (190)
      • engineered (214)
    Domains in SCOPe 2.08: d2f9na_
  • Chain 'B':
    Compound: alpha I tryptase
    Species: Homo sapiens [TaxId:9606]
    Gene: TPS1, TPS2, TPSAB1, TPSB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15157 (0-End)
      • engineered (45)
      • variant (184-185)
      • engineered (190)
      • engineered (214)
    Domains in SCOPe 2.08: d2f9nb_
  • Chain 'C':
    Compound: alpha I tryptase
    Species: Homo sapiens [TaxId:9606]
    Gene: TPS1, TPS2, TPSAB1, TPSB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15157 (0-End)
      • engineered (45)
      • variant (184-185)
      • engineered (190)
      • engineered (214)
    Domains in SCOPe 2.08: d2f9nc_
  • Chain 'D':
    Compound: alpha I tryptase
    Species: Homo sapiens [TaxId:9606]
    Gene: TPS1, TPS2, TPSAB1, TPSB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15157 (0-End)
      • engineered (45)
      • variant (184-185)
      • engineered (190)
      • engineered (214)
    Domains in SCOPe 2.08: d2f9nd_
  • Chain 'E':
    Compound: leupeptin
    Species: Actinomycetes Streptomyces roseus MA 839-A1, synthetic [TaxId:66430]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00487 (Start-2)
  • Chain 'F':
    Compound: leupeptin
    Species: Actinomycetes Streptomyces roseus MA 839-A1, synthetic [TaxId:66430]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00487 (Start-2)
  • Chain 'G':
    Compound: leupeptin
    Species: Actinomycetes Streptomyces roseus MA 839-A1, synthetic [TaxId:66430]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00487 (Start-2)
  • Chain 'H':
    Compound: leupeptin
    Species: Actinomycetes Streptomyces roseus MA 839-A1, synthetic [TaxId:66430]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00487 (Start-2)
  • Heterogens: BU3, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2f9nA (A:)
ivggqeaprskwpwqvslrvrdrywmhfcggslihpqwvltaahcvgpdvkdlatlrvql
reqhlyyqdqllpvsriivhpqfyiiqtgadialleleepvnissrvhtvmlppasetfp
pgmpcwvtgwgdvdndeplpppfplkqvkvpimenhicdakyhlgaytgddvriirddml
cagnsqrdscqgdsggplvckvngtwlqagvvswgegcaqpnrpgiytrvtyyldwihhy
vpkkp

    Sequence, based on observed residues (ATOM records): (download) 
    >2f9nA (A:)
ivggqeaprskwpwqvslrvrdrywmhfcggslihpqwvltaahcvgpdvkdlatlrvql
reqhlyyqdqllpvsriivhpqfyiiqtgadialleleepvnissrvhtvmlppasetfp
pgmpcwvtgwgdvdndeplpppfplkqvkvpimenhicdakyhlgaytgddvriirddml
cagnsqrdscqgdsggplvckvngtwlqagvvswgegcaqpnrpgiytrvtyyldwihhy
vpk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2f9nB (B:)
ivggqeaprskwpwqvslrvrdrywmhfcggslihpqwvltaahcvgpdvkdlatlrvql
reqhlyyqdqllpvsriivhpqfyiiqtgadialleleepvnissrvhtvmlppasetfp
pgmpcwvtgwgdvdndeplpppfplkqvkvpimenhicdakyhlgaytgddvriirddml
cagnsqrdscqgdsggplvckvngtwlqagvvswgegcaqpnrpgiytrvtyyldwihhy
vpkkp

    Sequence, based on observed residues (ATOM records): (download) 
    >2f9nB (B:)
ivggqeaprskwpwqvslrvrdrywmhfcggslihpqwvltaahcvgpdvkdlatlrvql
reqhlyyqdqllpvsriivhpqfyiiqtgadialleleepvnissrvhtvmlppasetfp
pgmpcwvtgwgdvdndeplpppfplkqvkvpimenhicdakyhlgaytgddvriirddml
cagnsqrdscqgdsggplvckvngtwlqagvvswgegcaqpnrpgiytrvtyyldwihhy
vpk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2f9nC (C:)
ivggqeaprskwpwqvslrvrdrywmhfcggslihpqwvltaahcvgpdvkdlatlrvql
reqhlyyqdqllpvsriivhpqfyiiqtgadialleleepvnissrvhtvmlppasetfp
pgmpcwvtgwgdvdndeplpppfplkqvkvpimenhicdakyhlgaytgddvriirddml
cagnsqrdscqgdsggplvckvngtwlqagvvswgegcaqpnrpgiytrvtyyldwihhy
vpkkp

    Sequence, based on observed residues (ATOM records): (download) 
    >2f9nC (C:)
ivggqeaprskwpwqvslrvrdrywmhfcggslihpqwvltaahcvgpdvkdlatlrvql
reqhlyyqdqllpvsriivhpqfyiiqtgadialleleepvnissrvhtvmlppasetfp
pgmpcwvtgwgdvdndeplpppfplkqvkvpimenhicdakyhlgaytgddvriirddml
cagnsqrdscqgdsggplvckvngtwlqagvvswgegcaqpnrpgiytrvtyyldwihhy
vpk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2f9nD (D:)
ivggqeaprskwpwqvslrvrdrywmhfcggslihpqwvltaahcvgpdvkdlatlrvql
reqhlyyqdqllpvsriivhpqfyiiqtgadialleleepvnissrvhtvmlppasetfp
pgmpcwvtgwgdvdndeplpppfplkqvkvpimenhicdakyhlgaytgddvriirddml
cagnsqrdscqgdsggplvckvngtwlqagvvswgegcaqpnrpgiytrvtyyldwihhy
vpkkp

    Sequence, based on observed residues (ATOM records): (download) 
    >2f9nD (D:)
ivggqeaprskwpwqvslrvrdrywmhfcggslihpqwvltaahcvgpdvkdlatlrvql
reqhlyyqdqllpvsriivhpqfyiiqtgadialleleepvnissrvhtvmlppasetfp
pgmpcwvtgwgdvdndeplpppfplkqvkvpimenhicdakyhlgaytgddvriirddml
cagnsqrdscqgdsggplvckvngtwlqagvvswgegcaqpnrpgiytrvtyyldwihhy
vpk

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.