PDB entry 2f9b
View 2f9b on RCSB PDB site
Description: Discovery of Novel Heterocyclic Factor VIIa Inhibitors
Class: hydrolase/blood clotting
Keywords: serine protease, short hydrogen bond, active site-directed inhibitor, HYDROLASE/BLOOD CLOTTING COMPLEX
Deposited on
2005-12-05, released
2006-02-28
The last revision prior to the SCOPe 2.06 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 2.54 Å
R-factor: 0.226
AEROSPACI score: 0.28
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'H':
Compound: Coagulation factor VII
Species: Homo sapiens [TaxId:9606]
Gene: F7
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2f9bh_ - Chain 'L':
Compound: Coagulation factor VII
Species: Homo sapiens [TaxId:9606]
Gene: F7
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2f9bl1, d2f9bl2 - Chain 'T':
Compound: tissue factor
Species: Homo sapiens [TaxId:9606]
Gene: F3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2f9bt1, d2f9bt2 - Heterogens: N1H, HOH
PDB Chain Sequences:
- Chain 'H':
Sequence; same for both SEQRES and ATOM records: (download)
>2f9bH (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp
- Chain 'L':
Sequence, based on SEQRES records: (download)
>2f9bL (L:)
anafleelrpgslereckeeqcsfeeareifkdaertklfwisysdgdqcasspcqnggs
ckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgtkrscrchegysl
ladgvsctptveypcgkipilekrnaskpqgr
Sequence, based on observed residues (ATOM records): (download)
>2f9bL (L:)
qcasspcqnggsckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgt
krscrchegyslladgvsctptveypcgkipile
- Chain 'T':
Sequence, based on SEQRES records: (download)
>2f9bT (T:)
gttntvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltd
eivkdvkqtylarvfsypagnvestgsageplyenspeftpyletnlgqptiqsfeqvgt
kvnvtvedertlvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvdk
genycfsvqavipsrtvnrkstdspvecmgqekgefre
Sequence, based on observed residues (ATOM records): (download)
>2f9bT (T:)
tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
dvkqtylarvfsypagnvestgsageplyenspeftpyletnlgdertlvrrnntflslr
dvfgkdliytlsvqavipsrtvnrkstds