PDB entry 2f98

View 2f98 on RCSB PDB site
Description: Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity.
Class: biosynthetic protein
Keywords: anthracycline, polyketide cyclase, stereoselectivity, aklavinone, BIOSYNTHETIC PROTEIN
Deposited on 2005-12-05, released 2006-02-14
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.195
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aklanonic Acid methyl Ester Cyclase, AknH
    Species: Streptomyces galilaeus [TaxId:33899]
    Database cross-references and differences (RAF-indexed):
    • GB AAF70112 (10-End)
      • cloning artifact (9)
    Domains in SCOPe 2.05: d2f98a1
  • Chain 'B':
    Compound: Aklanonic Acid methyl Ester Cyclase, AknH
    Species: Streptomyces galilaeus [TaxId:33899]
    Database cross-references and differences (RAF-indexed):
    • GB AAF70112 (10-End)
      • cloning artifact (9)
    Domains in SCOPe 2.05: d2f98b_
  • Chain 'C':
    Compound: Aklanonic Acid methyl Ester Cyclase, AknH
    Species: Streptomyces galilaeus [TaxId:33899]
    Database cross-references and differences (RAF-indexed):
    • GB AAF70112 (10-End)
      • cloning artifact (9)
    Domains in SCOPe 2.05: d2f98c_
  • Chain 'D':
    Compound: Aklanonic Acid methyl Ester Cyclase, AknH
    Species: Streptomyces galilaeus [TaxId:33899]
    Database cross-references and differences (RAF-indexed):
    • GB AAF70112 (10-End)
    Domains in SCOPe 2.05: d2f98d_
  • Heterogens: SO4, NGV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2f98A (A:)
mahhhhhhhrseqiaavrrmveayntgktddvadyihpeymnpgtleftslrgpelfain
vawvkktfseearleevgieeradwvrarlvlygrhvgemvgmaptgrlfsgeqihllhf
vdgkihhhrdwpdyqgtyrqlgepwpetehrrp

    Sequence, based on observed residues (ATOM records): (download) 
    >2f98A (A:)
rseqiaavrrmveayntgktddvadyihpeymnpgtleftslrgpelfainvawvkktfs
eearleevgieeradwvrarlvlygrhvgemvgmaptgrlfsgeqihllhfvdgkihhhr
dwpdyqgtyrqlgepwpeteh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2f98B (B:)
mahhhhhhhrseqiaavrrmveayntgktddvadyihpeymnpgtleftslrgpelfain
vawvkktfseearleevgieeradwvrarlvlygrhvgemvgmaptgrlfsgeqihllhf
vdgkihhhrdwpdyqgtyrqlgepwpetehrrp

    Sequence, based on observed residues (ATOM records): (download) 
    >2f98B (B:)
rseqiaavrrmveayntgktddvadyihpeymnpgtleftslrgpelfainvawvkktfs
eearleevgieeradwvrarlvlygrhvgemvgmaptgrlfsgeqihllhfvdgkihhhr
dwpdyqgtyrqlgepwpeteh

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2f98C (C:)
mahhhhhhhrseqiaavrrmveayntgktddvadyihpeymnpgtleftslrgpelfain
vawvkktfseearleevgieeradwvrarlvlygrhvgemvgmaptgrlfsgeqihllhf
vdgkihhhrdwpdyqgtyrqlgepwpetehrrp

    Sequence, based on observed residues (ATOM records): (download) 
    >2f98C (C:)
rseqiaavrrmveayntgktddvadyihpeymnpgtleftslrgpelfainvawvkktfs
eearleevgieeradwvrarlvlygrhvgemvgmaptgrlfsgeqihllhfvdgkihhhr
dwpdyqgtyrqlgepwpetehrr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2f98D (D:)
mahhhhhhhrseqiaavrrmveayntgktddvadyihpeymnpgtleftslrgpelfain
vawvkktfseearleevgieeradwvrarlvlygrhvgemvgmaptgrlfsgeqihllhf
vdgkihhhrdwpdyqgtyrqlgepwpetehrrp

    Sequence, based on observed residues (ATOM records): (download) 
    >2f98D (D:)
seqiaavrrmveayntgktddvadyihpeymnpgtleftslrgpelfainvawvkktfse
earleevgieeradwvrarlvlygrhvgemvgmaptgrlfsgeqihllhfvdgkihhhrd
wpdyqgtyrqlgepwpeteh