PDB entry 2f53
View 2f53 on RCSB PDB site
Description: Directed Evolution of Human T-cell Receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without apparent cross-reactivity
Class: immune system
Keywords: T-cell Receptor, CDR2, Phage Display, Mutant, High Affinity, NY-ESO-1
Deposited on
2005-11-25, released
2006-04-25
The last revision prior to the SCOP 1.73 freeze date was dated
2006-04-25, with a file datestamp of
2007-06-28.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.169
AEROSPACI score: 0.45
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: hla class I histocompatibility antigen
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.73: d2f53a1, d2f53a2 - Chain 'B':
Compound: Beta-2-microglobulin
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
- Uniprot P61769 (1-99)
- cloning artifact (0)
- engineered (91)
- Chain 'C':
Compound: Cancer/testis antigen 1B
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Chain 'D':
Compound: T-cell receptor, alpha chain
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
- Chain 'E':
Compound: T-cell receptor, beta chain
Species: HOMO SAPIENS
- Heterogens: NA, GOL, HOH