PDB entry 2f2f

View 2f2f on RCSB PDB site
Description: Crystal structure of cytolethal distending toxin (CDT) from Actinobacillus actinomycetemcomitans
Class: toxin
Keywords: Cytolethal distending toxin, CDT, Actinobacillus actinomycetemcomitans, crystal structure, oligomerization, stability and toxic activity
Deposited on 2005-11-16, released 2006-03-28
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.221
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytolethal distending toxin A
    Species: Aggregatibacter actinomycetemcomitans [TaxId:714]
    Gene: cdtA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2f2fa1
  • Chain 'B':
    Compound: Cytolethal distending toxin B
    Species: Aggregatibacter actinomycetemcomitans [TaxId:714]
    Gene: cdtB
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7DK12 (Start-282)
      • see remark 999 (280)
    Domains in SCOPe 2.03: d2f2fb1
  • Chain 'C':
    Compound: cytolethal distending toxin C
    Species: Aggregatibacter actinomycetemcomitans [TaxId:714]
    Gene: cdtC
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7DK11
      • see remark 999 (171)
    Domains in SCOPe 2.03: d2f2fc1
  • Chain 'D':
    Compound: Cytolethal distending toxin A
    Species: Aggregatibacter actinomycetemcomitans [TaxId:714]
    Gene: cdtA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2f2fd_
  • Chain 'E':
    Compound: Cytolethal distending toxin B
    Species: Aggregatibacter actinomycetemcomitans [TaxId:714]
    Gene: cdtB
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7DK12 (Start-282)
      • see remark 999 (280)
    Domains in SCOPe 2.03: d2f2fe_
  • Chain 'F':
    Compound: cytolethal distending toxin C
    Species: Aggregatibacter actinomycetemcomitans [TaxId:714]
    Gene: cdtC
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7DK11
      • see remark 999 (171)
    Domains in SCOPe 2.03: d2f2ff_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2f2fA (A:)
mkkflpglllmglvacssnqrmsdysqpesqsdlapkssttqfqpqpllskassmplnll
ssskngqvspsepsnfmtlmgqngalltvwalakrnwlwaypniysqdfgnirnwkiepg
khreyfrfvnqslgtcieaygnglihdtcsldklaqefellptdsgavviksvsqgrcvt
ynpvsptyystvtlstcdgateplrdqtwylappvleatavn

    Sequence, based on observed residues (ATOM records): (download) 
    >2f2fA (A:)
psepsnfmtlmgqngalltvwalakrnwlwaypniysqdfgnirnwkiepgkhreyfrfv
nqslgtcieaygnglihdtcsldklaqefellptdsgavviksvsqgrcvtynpvsptyy
stvtlstcdgateplrdqtwylappvleatavn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2f2fB (B:)
mqwvkqlnvvfctmlfsfssyanlsdfkvatwnlqgssavneskwninvrqllsgeqgad
ilmvqeagslpssavrtsrviqhggtpieeytwnlgtrsrpnmvyiyysrldvganrvnl
aivsrrqadeafivhsdssvlqsrpavgirigtdvfftvhalatggsdavslirnifttf
tsspssperrgyswmvvgdfnrapvnleaalrqepavsentiiiaptepthrsgnildya
ilhdahlprreqarerigaslmlnqlrsqitsdhfpvsfvhdr

    Sequence, based on observed residues (ATOM records): (download) 
    >2f2fB (B:)
nlsdfkvatwnlqgssavneskwninvrqllsgeqgadilmvqeagslpssavrtsrviq
hggtpieeytwnlgtrsrpnmvyiyysrldvganrvnlaivsrrqadeafivhsdssvlq
srpavgirigtdvfftvhalatggsdavslirnifttftsspssperrgyswmvvgdfnr
apvnleaalrqepavsentiiiaptepthrsgnildyailhdahlprreqarerigaslm
lnqlrsqitsdhfpvsfvhdr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2f2fC (C:)
mkkyllsfllsmiltltshaesnpdpttypdvelsppprislrslltaqpikndhydshn
ylsthwelidykgkeyeklrdggtlvqfkvvgaakcfafpgegttdckdidhtvfnlipt
ntgaflikdallgfcmtshdfddlrlepcgisvsgrtfslayqwgilppfgpskilrppv
grnqgs

    Sequence, based on observed residues (ATOM records): (download) 
    >2f2fC (C:)
dpttypdvelsppprislrslltaqpikndhydshnylsthwelidykgkeyeklrdggt
lvqfkvvgaakcfafpgegttdckdidhtvfnliptntgaflikdallgfcmtshdfddl
rlepcgisvsgrtfslayqwgilppfgpskilrp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2f2fD (D:)
mkkflpglllmglvacssnqrmsdysqpesqsdlapkssttqfqpqpllskassmplnll
ssskngqvspsepsnfmtlmgqngalltvwalakrnwlwaypniysqdfgnirnwkiepg
khreyfrfvnqslgtcieaygnglihdtcsldklaqefellptdsgavviksvsqgrcvt
ynpvsptyystvtlstcdgateplrdqtwylappvleatavn

    Sequence, based on observed residues (ATOM records): (download) 
    >2f2fD (D:)
psepsnfmtlmgqngalltvwalakrnwlwaypniysqdfgnirnwkiepgkhreyfrfv
nqslgtcieaygnglihdtcsldklaqefellptdsgavviksvsqgrcvtynpvsptyy
stvtlstcdgateplrdqtwylappvleatavn

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2f2fE (E:)
mqwvkqlnvvfctmlfsfssyanlsdfkvatwnlqgssavneskwninvrqllsgeqgad
ilmvqeagslpssavrtsrviqhggtpieeytwnlgtrsrpnmvyiyysrldvganrvnl
aivsrrqadeafivhsdssvlqsrpavgirigtdvfftvhalatggsdavslirnifttf
tsspssperrgyswmvvgdfnrapvnleaalrqepavsentiiiaptepthrsgnildya
ilhdahlprreqarerigaslmlnqlrsqitsdhfpvsfvhdr

    Sequence, based on observed residues (ATOM records): (download) 
    >2f2fE (E:)
nlsdfkvatwnlqgssavneskwninvrqllsgeqgadilmvqeagslpssavrtsrviq
hggtpieeytwnlgtrsrpnmvyiyysrldvganrvnlaivsrrqadeafivhsdssvlq
srpavgirigtdvfftvhalatggsdavslirnifttftsspssperrgyswmvvgdfnr
apvnleaalrqepavsentiiiaptepthrsgnildyailhdahlprreqarerigaslm
lnqlrsqitsdhfpvsfvhdr

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2f2fF (F:)
mkkyllsfllsmiltltshaesnpdpttypdvelsppprislrslltaqpikndhydshn
ylsthwelidykgkeyeklrdggtlvqfkvvgaakcfafpgegttdckdidhtvfnlipt
ntgaflikdallgfcmtshdfddlrlepcgisvsgrtfslayqwgilppfgpskilrppv
grnqgs

    Sequence, based on observed residues (ATOM records): (download) 
    >2f2fF (F:)
dpttypdvelsppprislrslltaqpikndhydshnylsthwelidykgkeyeklrdggt
lvqfkvvgaakcfafpgegttdckdidhtvfnliptntgaflikdallgfcmtshdfddl
rlepcgisvsgrtfslayqwgilppfgpskilrp