PDB entry 2f26

View 2f26 on RCSB PDB site
Description: Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant
Class: hydrolase
Keywords: SIALIDASE, NEURAMINIDASE, GANGLIOSIDE, DRUG DESIGN, hydrolase
Deposited on 2005-11-15, released 2006-11-21
The last revision prior to the SCOPe 2.02 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.58 Å
R-factor: 0.209
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Sialidase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y3R4
      • engineered (112-113)
    Domains in SCOPe 2.02: d2f26a_
  • Heterogens: CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2f26A (A:)
gsmaslpvlqkesvfqsgahayripallylpgqqsllafaeqraskkdehaelivlrrgd
ydapthqvqwqaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvtqeqqlqtr
anvtrlcqvtstdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpa
yayrklhpiqrpipsafcflshdhgrtwarghfvaqdtlecqvaevetgeqrvvtlnars
hlrarvqaqstndgldfqesqlvkklvepppqgcqgsvisfpsprsgpgspaqwllythp
thswqradlgaylnprppapeawsepvllakgscaysdlqsmgtgpdgsplfgclyeand
yeeivflmftlkqafpaeylpq

    Sequence, based on observed residues (ATOM records): (download) 
    >2f26A (A:)
lpvlqkesvfqsgahayripallylpgqqsllafaeqrelivlrrgdydapthqvqwqaq
evvaqarldghrsmnpcplydaqtgtlflffiaipgqvtqeqqlqtranvtrlcqvtstd
hgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpayayrklhpiqrpi
psafcflshdhgrtwarghfvaqdtlecqvaevetgeqrvvtlnarshlrarvqaqstnd
gldfqesqlvkklvepppqgcqgsvisfpsprspaqwllythpthswqradlgaylnprp
papeawsepvllakgscaysdlqsmgtgpdgsplfgclyeandyeeivflmftlkqafpa
ey