PDB entry 2f17

View 2f17 on RCSB PDB site
Description: Mouse Thiamin Pyrophosphokinase in a Ternary Complex with Pyrithiamin Pyrophosphate and AMP at 2.5 angstrom
Class: transferase
Keywords: BETA BARREL, ALPHA/BETA/ALPHA SANDWICH, pyrophosphokinase, AMP, TRANSFERASE
Deposited on 2005-11-14, released 2005-11-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.237
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thiamin pyrophosphokinase 1
    Species: Mus musculus [TaxId:10090]
    Gene: Tpk1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9R0M5 (20-262)
      • expression tag (8-9)
      • cloning artifact (10-19)
    Domains in SCOPe 2.08: d2f17a1, d2f17a2, d2f17a3
  • Chain 'B':
    Compound: Thiamin pyrophosphokinase 1
    Species: Mus musculus [TaxId:10090]
    Gene: Tpk1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2f17b1, d2f17b2
  • Heterogens: MG, SO4, EPE, PYI, AMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2f17A (A:)
mgsshhhhhhssglvprgshmehaftplepllptgnlkyclvvlnqpldarfrhlwkkal
lracadgganhlydltegeresflpefvsgdfdsirpevkeyytkkgcdlistpdqdhtd
ftkclqvlqrkieekelqvdvivtlgglggrfdqimasvntlfqathitpvpiiiiqkds
liyllqpgkhrlhvdtgmegswcglipvgqpcnqvtttglkwnltndvlgfgtlvstsnt
ydgsglvtvetdhpllwtmaiks

    Sequence, based on observed residues (ATOM records): (download) 
    >2f17A (A:)
hhssglvprgshmehaftplepllptgnlkyclvvlnqpldarfrhlwkkallracadgg
anhlydltegeresflpefvsgdfdsirpevkeyytkkgcdlistpdqdhtdftkclqvl
qrkieekelqvdvivtlgglggrfdqimasvntlfqathitpvpiiiiqkdsliyllqpg
khrlhvdtgmegswcglipvgqpcnqvtttglkwnltndvlgfgtlvstsntydgsglvt
vetdhpllwtmaiks

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2f17B (B:)
mgsshhhhhhssglvprgshmehaftplepllptgnlkyclvvlnqpldarfrhlwkkal
lracadgganhlydltegeresflpefvsgdfdsirpevkeyytkkgcdlistpdqdhtd
ftkclqvlqrkieekelqvdvivtlgglggrfdqimasvntlfqathitpvpiiiiqkds
liyllqpgkhrlhvdtgmegswcglipvgqpcnqvtttglkwnltndvlgfgtlvstsnt
ydgsglvtvetdhpllwtmaiks

    Sequence, based on observed residues (ATOM records): (download) 
    >2f17B (B:)
mehaftplepllptgnlkyclvvlnqpldarfrhlwkkallracadgganhlydlteger
esflpefvsgdfdsirpevkeyytkkgcdlistpdqdhtdftkclqvlqrkieekelqvd
vivtlgglggrfdqimasvntlfqathitpvpiiiiqkdsliyllqpgkhrlhvdtgmeg
swcglipvgqpcnqvtttglkwnltndvlgfgtlvstsntydgsglvtvetdhpllwtma
iks