PDB entry 2f13
View 2f13 on RCSB PDB site
Description: Crystal Structure of the Human Sialidase Neu2 in Complex with 2',3'- dihydroxypropyl ether mimetic Inhibitor
Class: hydrolase
Keywords: SIALIDASE, NEURAMINIDASE, INFLUENZA VIRUS, DRUG DESIGN, hydrolase
Deposited on
2005-11-14, released
2006-11-21
The last revision prior to the SCOPe 2.02 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 2.26 Å
R-factor: 0.194
AEROSPACI score: 0.37
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Sialidase 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.02: d2f13a_ - Heterogens: PO4, DYM, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2f13A (A:)
gsmaslpvlqkesvfqsgahayripallylpgqqsllafaeqraskkdehaelivlrrgd
ydapthqvqwqaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvteqqqlqtr
anvtrlcqvtstdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpa
yayrklhpiqrpipsafcflshdhgrtwarghfvaqdtlecqvaevetgeqrvvtlnars
hlrarvqaqstndgldfqesqlvkklvepppqgcqgsvisfpsprsgpgspaqwllythp
thswqradlgaylnprppapeawsepvllakgscaysdlqsmgtgpdgsplfgclyeand
yeeivflmftlkqafpaeylpq
Sequence, based on observed residues (ATOM records): (download)
>2f13A (A:)
slpvlqkesvfqsgahayripallylpgqqsllafaeqraaelivlrrgdydapthqvqw
qaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqranvtrlcqvtstdhgrtws
sprdltdaaigpayrewstfavgpghclqlndrarslvvpayayrklhpiqrpipsafcf
lshdhgrtwarghfvaqdtlecqvaeveeqrvvtlnarshlrarvqaqstndgldfqesq
lvkklvepppqgcqgsvisfpspraqwllythpthswqradlgaylnprppapeawsepv
llakgscaysdlqsmgtgpdgsplfgclyeandyeeivflmftlkqafpae