PDB entry 2ewy

View 2ewy on RCSB PDB site
Description: Crystal structure of human BACE2 in complex with a hydroxyethylenamine transition-state inhibitor
Class: hydrolase
Keywords: BACE2, aspartic protease, HYDROLASE
Deposited on 2005-11-07, released 2006-11-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.227
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-secretase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BACE2, ASP21
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ewya_
  • Chain 'B':
    Compound: Beta-secretase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BACE2, ASP21
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ewyb_
  • Chain 'C':
    Compound: Beta-secretase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BACE2, ASP21
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ewyc_
  • Chain 'D':
    Compound: Beta-secretase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BACE2, ASP21
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ewyd_
  • Heterogens: DBO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2ewyA (A:)
    lamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdtersst
    yrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwngil
    glayatlakpsssletffdslvtqanipnvfsmqmcgaglpvagsgtnggslvlggieps
    lykgdiwytpikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqkvfd
    avveavaraslipefsdgfwtgsqlacwtnsetpwsyfpkisiylrdenssrsfritilp
    qlyiqpmmgaglnyecyrfgispstnalvigatvmegfyvifdraqkrvgfaaspcaeia
    gaavseisgpfstedvasncvpa
    

    Sequence, based on observed residues (ATOM records): (download)
    >2ewyA (A:)
    lamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdtersst
    yrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwngil
    glayatlakpsssletffdslvtqanipnvfsmqmcganggslvlggiepslykgdiwyt
    pikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqkvfdavveavara
    slipefsdgfwtgsqlacwtnsetpwsyfpkisiylrdenssrsfritilpqlyiqpmmg
    aglnyecyrfgispstnalvigatvmegfyvifdraqkrvgfaaspcaeiagaavseisg
    pfstedvasncvpa
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2ewyB (B:)
    lamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdtersst
    yrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwngil
    glayatlakpsssletffdslvtqanipnvfsmqmcgaglpvagsgtnggslvlggieps
    lykgdiwytpikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqkvfd
    avveavaraslipefsdgfwtgsqlacwtnsetpwsyfpkisiylrdenssrsfritilp
    qlyiqpmmgaglnyecyrfgispstnalvigatvmegfyvifdraqkrvgfaaspcaeia
    gaavseisgpfstedvasncvpa
    

    Sequence, based on observed residues (ATOM records): (download)
    >2ewyB (B:)
    lamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdtersst
    yrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwngil
    glayatlakpsssletffdslvtqanipnvfsmqmcganggslvlggiepslykgdiwyt
    pikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqkvfdavveavara
    slipefsdgfwtgsqlacwtnsetpwsyfpkisiylrdenssrsfritilpqlyiqpmmg
    aglnyecyrfgispstnalvigatvmegfyvifdraqkrvgfaaspcaeiagaavseisg
    pfstedvasncvpa
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >2ewyC (C:)
    lamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdtersst
    yrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwngil
    glayatlakpsssletffdslvtqanipnvfsmqmcgaglpvagsgtnggslvlggieps
    lykgdiwytpikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqkvfd
    avveavaraslipefsdgfwtgsqlacwtnsetpwsyfpkisiylrdenssrsfritilp
    qlyiqpmmgaglnyecyrfgispstnalvigatvmegfyvifdraqkrvgfaaspcaeia
    gaavseisgpfstedvasncvpa
    

    Sequence, based on observed residues (ATOM records): (download)
    >2ewyC (C:)
    lamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdtersst
    yrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwngil
    glayatlakpsssletffdslvtqanipnvfsmqmcganggslvlggiepslykgdiwyt
    pikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqkvfdavveavara
    slipefsdgfwtgsqlacwtnsetpwsyfpkisiylrdenssrsfritilpqlyiqpmmg
    aglnyecyrfgispstnalvigatvmegfyvifdraqkrvgfaaspcaeiagaavseisg
    pfstedvasncvpa
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >2ewyD (D:)
    lamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdtersst
    yrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwngil
    glayatlakpsssletffdslvtqanipnvfsmqmcgaglpvagsgtnggslvlggieps
    lykgdiwytpikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqkvfd
    avveavaraslipefsdgfwtgsqlacwtnsetpwsyfpkisiylrdenssrsfritilp
    qlyiqpmmgaglnyecyrfgispstnalvigatvmegfyvifdraqkrvgfaaspcaeia
    gaavseisgpfstedvasncvpa
    

    Sequence, based on observed residues (ATOM records): (download)
    >2ewyD (D:)
    lamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdtersst
    yrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwngil
    glayatlakpsssletffdslvtqanipnvfsmqmcganggslvlggiepslykgdiwyt
    pikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqkvfdavveavara
    slipefsdgfwtgsqlacwtnsetpwsyfpkisiylrdenssrsfritilpqlyiqpmmg
    aglnyecyrfgispstnalvigatvmegfyvifdraqkrvgfaaspcaeiagaavseisg
    pfstedvasncvpa