PDB entry 2ewp

View 2ewp on RCSB PDB site
Description: Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domaind with tamoxifen analog GSK5182
Class: transcription
Keywords: Tamoxifen, ERR, Estrogen Related Receptor, Orphan Receptor, TRANSCRIPTION
Deposited on 2005-11-04, released 2006-05-09
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-10-18, with a file datestamp of 2017-10-13.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen-related receptor gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: ESRRG, ERR3, ERRG2, KIAA0832, NR3B3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2ewpa_
  • Chain 'B':
    Compound: Estrogen-related receptor gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: ESRRG, ERR3, ERRG2, KIAA0832, NR3B3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2ewpb_
  • Chain 'C':
    Compound: Estrogen-related receptor gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: ESRRG, ERR3, ERRG2, KIAA0832, NR3B3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2ewpc_
  • Chain 'D':
    Compound: Estrogen-related receptor gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: ESRRG, ERR3, ERRG2, KIAA0832, NR3B3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2ewpd_
  • Chain 'E':
    Compound: Estrogen-related receptor gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: ESRRG, ERR3, ERRG2, KIAA0832, NR3B3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2ewpe_
  • Heterogens: TXF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2ewpA (A:)
pynkivshllvaepekiyampdptvpdsdikalttlcdladrelvviigwakhipgfstl
sladqmsllqsawmeililgvvyrslsfedelvyaddyimdedqsklaglldlnnailql
vkkyksmklekeefvtlkaialansdsmhiedveavqklqdvlhealqdyeagqhmedpr
ragkmlmtlpllrqtstkavqhfyniklegkvpmhklflemleakv

    Sequence, based on observed residues (ATOM records): (download) 
    >2ewpA (A:)
pynkivshllvaepekiyampdptvpdsdikalttlcdladrelvviigwakhipgfstl
sladqmsllqsawmeililgvvyrslsfedelvyaddyimdedqsklaglldlnnailql
vkkyksmklekeefvtlkaialansdsmhiedveavqklqdvlhealqdyeagqhmedpr
ragkmlmtlpllrqtstkavqhfyniklegkvpmhklflemlea

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2ewpB (B:)
pynkivshllvaepekiyampdptvpdsdikalttlcdladrelvviigwakhipgfstl
sladqmsllqsawmeililgvvyrslsfedelvyaddyimdedqsklaglldlnnailql
vkkyksmklekeefvtlkaialansdsmhiedveavqklqdvlhealqdyeagqhmedpr
ragkmlmtlpllrqtstkavqhfyniklegkvpmhklflemleakv

    Sequence, based on observed residues (ATOM records): (download) 
    >2ewpB (B:)
pynkivshllvaepekiyampdptvpdsdikalttlcdladrelvviigwakhipgfstl
sladqmsllqsawmeililgvvyrslsfedelvyaddyimdedqsklaglldlnnailql
vkkyksmklekeefvtlkaialansdsmhiedveavqklqdvlhealqdyeagqhmedpr
ragkmlmtlpllrqtstkavqhfyniklegkvpmhklflemlea

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2ewpC (C:)
pynkivshllvaepekiyampdptvpdsdikalttlcdladrelvviigwakhipgfstl
sladqmsllqsawmeililgvvyrslsfedelvyaddyimdedqsklaglldlnnailql
vkkyksmklekeefvtlkaialansdsmhiedveavqklqdvlhealqdyeagqhmedpr
ragkmlmtlpllrqtstkavqhfyniklegkvpmhklflemleakv

    Sequence, based on observed residues (ATOM records): (download) 
    >2ewpC (C:)
ynkivshllvaepekiyampdptvpdsdikalttlcdladrelvviigwakhipgfstls
ladqmsllqsawmeililgvvyrslsfedelvyaddyimdedqsklaglldlnnailqlv
kkyksmklekeefvtlkaialansdsmhiedveavqklqdvlhealqdyeagqhmedprr
agkmlmtlpllrqtstkavqhfyniklegkvpmhklflemlea

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2ewpD (D:)
pynkivshllvaepekiyampdptvpdsdikalttlcdladrelvviigwakhipgfstl
sladqmsllqsawmeililgvvyrslsfedelvyaddyimdedqsklaglldlnnailql
vkkyksmklekeefvtlkaialansdsmhiedveavqklqdvlhealqdyeagqhmedpr
ragkmlmtlpllrqtstkavqhfyniklegkvpmhklflemleakv

    Sequence, based on observed residues (ATOM records): (download) 
    >2ewpD (D:)
nkivshllvaepekiyampdptvpdsdikalttlcdladrelvviigwakhipgfstlsl
adqmsllqsawmeililgvvyrslsfedelvyaddyimdedqsklaglldlnnailqlvk
kyksmklekeefvtlkaialansdsmhiedveavqklqdvlhealqdyeagqhmedprra
gkmlmtlpllrqtstkavqhfyniklegkvpmhklflemle

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2ewpE (E:)
pynkivshllvaepekiyampdptvpdsdikalttlcdladrelvviigwakhipgfstl
sladqmsllqsawmeililgvvyrslsfedelvyaddyimdedqsklaglldlnnailql
vkkyksmklekeefvtlkaialansdsmhiedveavqklqdvlhealqdyeagqhmedpr
ragkmlmtlpllrqtstkavqhfyniklegkvpmhklflemleakv

    Sequence, based on observed residues (ATOM records): (download) 
    >2ewpE (E:)
ivshllvaepekiyampdptvpdsdikalttlcdladrelvviigwakhipgfstlslad
qmsllqsawmeililgvvyrslsfedelvyaddyimdedqsklaglldlnnailqlvkky
ksmklekeefvtlkaialansdsmhiedveavqklqdvlhealqdyeedprragkmlmtl
pllrqtstkavqhfyniklegkvpmhklflemle