PDB entry 2erz
View 2erz on RCSB PDB site
Description: Crystal Structure of c-AMP Dependent Kinase (PKA) bound to hydroxyfasudil
Class: transferase
Keywords: fasudil kinase, TRANSFERASE
Deposited on
2005-10-25, released
2005-11-08
The last revision prior to the SCOPe 2.08 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.227
AEROSPACI score: 0.35
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'E':
Compound: cAMP-dependent protein kinase, alpha-catalytic subunit
Species: Mus musculus [TaxId:10090]
Gene: Prkaca, Pkaca
Database cross-references and differences (RAF-indexed):
- Uniprot P05132 (Start-350)
- modified residue (197)
- modified residue (338)
Domains in SCOPe 2.08: d2erze_ - Chain 'I':
Compound: cAMP-dependent protein kinase inhibitor, alpha form
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Heterogens: HFS, HOH
PDB Chain Sequences:
- Chain 'E':
Sequence, based on SEQRES records: (download)
>2erzE (E:)
mgnaaaakkgseqesvkeflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvml
vkhkesgnhyamkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymv
meyvaggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgy
iqvtdfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppff
adqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfat
tdwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkeftef
Sequence, based on observed residues (ATOM records): (download)
>2erzE (E:)
vkeflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvmlvkhkesgnhyamkil
dkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvaggemfshlrr
igrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrvkgr
twtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekivsgk
vrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkveapf
ipkfkgpgdtsnfddyeeeeirvsinekcgkeftef
- Chain 'I':
No sequence available.