PDB entry 2erj

View 2erj on RCSB PDB site
Description: Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2
Class: immune system/cytokine
Keywords: interleukin-2, interleukin-2 alpha receptor, interleukin-2 beta receptor, interleukin-2 gamma receptor
Deposited on 2005-10-25, released 2006-02-21
The last revision prior to the SCOP 1.73 freeze date was dated 2006-03-07, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.223
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Interleukin-2 receptor alpha chain
    Species: HOMO SAPIENS
    Gene: IL2RA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01589 (5-End)
      • engineered (53)
    Domains in SCOP 1.73: d2erja1, d2erja2
  • Chain 'B':
    Compound: Interleukin-2 receptor beta chain
    Species: HOMO SAPIENS
    Gene: IL2RB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14784 (Start-210)
      • his tag (211-213)
    Domains in SCOP 1.73: d2erjb1, d2erjb2
  • Chain 'C':
    Compound: Cytokine receptor common gamma chain
    Species: HOMO SAPIENS
    Gene: IL2RG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31785
      • engineered (57)
    Domains in SCOP 1.73: d2erjc1, d2erjc2
  • Chain 'D':
    Compound: interleukin-2
    Species: HOMO SAPIENS
    Gene: IL2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60568 (Start-132)
      • engineered (124)
    Domains in SCOP 1.73: d2erjd1
  • Chain 'E':
    Compound: Interleukin-2 receptor alpha chain
    Species: HOMO SAPIENS
    Gene: IL2RA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01589 (5-End)
      • engineered (53)
    Domains in SCOP 1.73: d2erje1, d2erje2
  • Chain 'F':
    Compound: Interleukin-2 receptor beta chain
    Species: HOMO SAPIENS
    Gene: IL2RB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14784 (Start-210)
      • his tag (211-213)
    Domains in SCOP 1.73: d2erjf1, d2erjf2
  • Chain 'G':
    Compound: Cytokine receptor common gamma chain
    Species: HOMO SAPIENS
    Gene: IL2RG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31785
      • engineered (57)
    Domains in SCOP 1.73: d2erjg1, d2erjg2
  • Chain 'H':
    Compound: interleukin-2
    Species: HOMO SAPIENS
    Gene: IL2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60568 (Start-132)
      • engineered (124)
    Domains in SCOP 1.73: d2erjh1
  • Heterogens: NAG

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2erjA (A:)
gmlslelcdddppeiphatfkamaykegtmlnceckrgfrriksgslymlctgssshssw
dnqcqctssatrsttkqvtpqpeeqkerkttemqspmqpvdqaslpghcrepppweneat
eriyhfvvgqmvyyqcvqgyralhrgpaesvckmthgktrwtqpqlictgemetsqfpge
ekpqaspegrpesetsclvtttdfqiqtemaatmetstghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2erjA (A:)
elcdddppeiphatfkamaykegtmlnceckrgfrriksgslymlctgssshsswdnqcq
ctsslpghcrepppweneateriyhfvvgqmvyyqcvqgyralhrgpaesvckmthgktr
wtqpqlictg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2erjB (B:)
gmlslavngtsqftcfynsraniscvwsqdgalqdtscqvhawpdrrrwnqtcellpvsq
aswacnlilgapdsqklttvdivtlrvlcregvrwrvmaiqdfkpfenlrlmapislqvv
hvethrcnisweisqashyferhlefeartlspghtweeaplltlkqkqewicletltpd
tqyefqvrvkplqgefttwspwsqplafrtktghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2erjB (B:)
sqftcfynsraniscvwsqdgalqdtscqvhawpdrrrwnqtcellpvsqaswacnlilg
apdsqklttvdivtlrvlcregvrwrvmaiqdfkpfenlrlmapislqvvhvethrcnis
weisqashyferhlefeartlspghtweeaplltlkqkqewicletltpdtqyefqvrvk
plqgefttwspwsqplafrtktgh

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2erjC (C:)
gmlsllnttiltpngnedttadfflttmptdslsvstlplpevqcfvfnveymnctwqss
sepqptnltlhywyknsdndkvqkcshylfseeitsgcqlqkkeihlyqtfvvqlqdpre
prrqatqmlklqnlvipwapenltlhklsesqlelnwnnrflnhclehlvqyrtdwdhsw
teqsvdyrhkfslpsvdgqkrytfrvrsrfnplcgsaqhwsewshpihwgsntskenprt
ghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2erjC (C:)
tlplpevqcfvfnveymnctwqsssepqptnltlhywyknsdndkvqkcshylfseeits
gcqlqkkeihlyqtfvvqlqdpreprrqatqmlklqnlvipwapenltlhklsesqleln
wnnrflnhclehlvqyrtdwdhswteqsvdyrhkfslpsvdgqkrytfrvrsrfnplcgs
aqhwsewshpihwgs

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2erjD (D:)
aptssstkktqlqlehllldlqmilnginnyknpkltrmltfkfympkkatelkhlqcle
eelkpleevlnlaqsknfhlrprdlisninvivlelkgsettfmceyadetativeflnr
witfaqsiistlt

    Sequence, based on observed residues (ATOM records): (download) 
    >2erjD (D:)
tssstkktqlqlehllldlqmilnginnyknpkltrmltfkfympkkatelkhlqcleee
lkpleevlnlaqsknfhlrprdlisninvivlelkgsettfmceyadetativeflnrwi
tfaqsiistlt

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2erjE (E:)
gmlslelcdddppeiphatfkamaykegtmlnceckrgfrriksgslymlctgssshssw
dnqcqctssatrsttkqvtpqpeeqkerkttemqspmqpvdqaslpghcrepppweneat
eriyhfvvgqmvyyqcvqgyralhrgpaesvckmthgktrwtqpqlictgemetsqfpge
ekpqaspegrpesetsclvtttdfqiqtemaatmetstghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2erjE (E:)
elcdddppeiphatfkamaykegtmlnceckrgfrriksgslymlctgssshsswdnqcq
ctssalpghcrepppweneateriyhfvvgqmvyyqcvqgyralhrgpaesvckmthgkt
rwtqpqlictg

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2erjF (F:)
gmlslavngtsqftcfynsraniscvwsqdgalqdtscqvhawpdrrrwnqtcellpvsq
aswacnlilgapdsqklttvdivtlrvlcregvrwrvmaiqdfkpfenlrlmapislqvv
hvethrcnisweisqashyferhlefeartlspghtweeaplltlkqkqewicletltpd
tqyefqvrvkplqgefttwspwsqplafrtktghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2erjF (F:)
sqftcfynsraniscvwsqdgdtscqvhawpdrrrwnqtcellpvsqaswacnlilgapd
sqklttvdivtlrvlcregvrwrvmaiqdfkpfenlrlmapislqvvhvethrcniswei
sqashyferhlefeartlspghtweeaplltlkqkqewicletltpdtqyefqvrvkplq
gefttwspwsqplafrtktgh

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >2erjG (G:)
gmlsllnttiltpngnedttadfflttmptdslsvstlplpevqcfvfnveymnctwqss
sepqptnltlhywyknsdndkvqkcshylfseeitsgcqlqkkeihlyqtfvvqlqdpre
prrqatqmlklqnlvipwapenltlhklsesqlelnwnnrflnhclehlvqyrtdwdhsw
teqsvdyrhkfslpsvdgqkrytfrvrsrfnplcgsaqhwsewshpihwgsntskenprt
ghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2erjG (G:)
tlplpevqcfvfnveymnctwqsssepqptnltlhywyknsdndkvqkcshylfseeits
gcqlqkkeihlyqtfvvqlqdpreprrqatqmlklqnlvipwapenltlhklsesqleln
wnnrflnhclehlvqyrtdwdhswteqsvdyrhkfslpsvdgqkrytfrvrsrfnplcgs
aqhwsewshpihwgs

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >2erjH (H:)
aptssstkktqlqlehllldlqmilnginnyknpkltrmltfkfympkkatelkhlqcle
eelkpleevlnlaqsknfhlrprdlisninvivlelkgsettfmceyadetativeflnr
witfaqsiistlt

    Sequence, based on observed residues (ATOM records): (download) 
    >2erjH (H:)
tssstkktqlqlehllldlqmilnginnyknpkltrmltfkfympkkatelkhlqcleee
lkpleevlnlaqsknfhlrprdlisninvivlelkgsettfmceyadetativeflnrwi
tfaqsiistlt