PDB entry 2eb3

View 2eb3 on RCSB PDB site
Description: Crystal structure of mutated EGFR kinase domain (L858R) in complex with AMPPNP
Class: transferase
Keywords: Kinase, Tyrosine-protein kinase, Receptor, Transferase, Phosphorylation, ATP-binding, Disease mutation, Transmembrane, Cell cycle, EC 2.7.10.1, Structural Genomics, NPPSFA, National Project on Protein Structural and Functional Analyses, RIKEN Structural Genomics/Proteomics Initiative, RSGI
Deposited on 2007-02-06, released 2008-02-12
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-03-07, with a file datestamp of 2012-03-02.
Experiment type: XRAY
Resolution: 2.84 Å
R-factor: 0.19
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • see remark 999 (169)
    Domains in SCOPe 2.05: d2eb3a_
  • Heterogens: ANP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2eb3A (A:)
gamgirsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelr
eatspkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdn
igsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaeeke
yhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissile
kgerlpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermh
lpsptdsnfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >2eb3A (A:)
geapnqallrilketefkkikvlgsafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgraklvpikwmalesilhri
ythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvkc
wmidadsrpkfreliiefskmardpqrylviqgdermhlpedmddvvdadeyli