PDB entry 2e7a
View 2e7a on RCSB PDB site
Description: TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity
Class: cytokine
Keywords: Tumor necrosis factor, Trimer, antagonistic activity, TNFR1 specific, phage display system, CYTOKINE
Deposited on
2007-01-09, released
2007-11-13
The last revision prior to the SCOPe 2.01 freeze date was dated
2009-02-24, with a file datestamp of
2009-02-03.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.198
AEROSPACI score: 0.5
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Tumor necrosis factor
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P01375 (Start-156)
- engineered (10)
- engineered (64)
- engineered (83-89)
- engineered (97)
- engineered (111)
- engineered (127)
Domains in SCOPe 2.01: d2e7aa_ - Chain 'B':
Compound: Tumor necrosis factor
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P01375 (Start-156)
- engineered (10)
- engineered (64)
- engineered (83-89)
- engineered (97)
- engineered (111)
- engineered (127)
Domains in SCOPe 2.01: d2e7ab_ - Chain 'C':
Compound: Tumor necrosis factor
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P01375 (Start-156)
- engineered (10)
- engineered (64)
- engineered (83-89)
- engineered (97)
- engineered (111)
- engineered (127)
Domains in SCOPe 2.01: d2e7ac_ - Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2e7aA (A:)
vrsssrtpsdmpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliys
qvlfsgqgcpsthvllthtisristthnqpvnllsairspcqretpegaeanpwyepiyl
ggvfqlepgdrlsaeinrpdyldfaesgqvyfgiial
Sequence, based on observed residues (ATOM records): (download)
>2e7aA (A:)
psdmpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfsgq
gcpsthvllthtisristthnqpvnllsairspcqretpegaeanpwyepiylggvfqle
pgdrlsaeinrpdyldfaesgqvyfgiial
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2e7aB (B:)
vrsssrtpsdmpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliys
qvlfsgqgcpsthvllthtisristthnqpvnllsairspcqretpegaeanpwyepiyl
ggvfqlepgdrlsaeinrpdyldfaesgqvyfgiial
Sequence, based on observed residues (ATOM records): (download)
>2e7aB (B:)
psdmpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfsgq
gcpsthvllthtisristthnqpvnllsairspcqanpwyepiylggvfqlepgdrlsae
inrpdyldfaesgqvyfgiial
- Chain 'C':
Sequence, based on SEQRES records: (download)
>2e7aC (C:)
vrsssrtpsdmpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliys
qvlfsgqgcpsthvllthtisristthnqpvnllsairspcqretpegaeanpwyepiyl
ggvfqlepgdrlsaeinrpdyldfaesgqvyfgiial
Sequence, based on observed residues (ATOM records): (download)
>2e7aC (C:)
psdmpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfsgq
gcpsthvllthtisristthnqpvnllsairspcqranpwyepiylggvfqlepgdrlsa
einrpdyldfaesgqvyfgiial