PDB entry 2e2d

View 2e2d on RCSB PDB site
Description: Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2
Class: hydrolase/hydrolase inhibitor
Keywords: matrix metalloproteinase/MMP; collagenase; tissue inhibitor of metalloproteinases/TIMP; complex, flexibility, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
Deposited on 2006-11-11, released 2007-03-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.201
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Matrix metallopeptidase 13
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2e2da_
  • Chain 'C':
    Compound: metalloproteinase inhibitor 2
    Species: Bos taurus [TaxId:9913]
    Gene: TIMP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P16368 (1-179)
      • cloning artifact (0)
    Domains in SCOPe 2.07: d2e2dc2, d2e2dc3
  • Heterogens: ZN, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2e2dA (A:)
    ynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
    misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
    fghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygp
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2e2dC (C:)
    cscspvhpqqafcnadivirakavnkkevdsgndiygnpikriqyeikqikmfkgpdqdi
    efiytapaaavcgvsldiggkkeyliagkaegngnmhitlcdfivpwdtlsatqkkslnh
    ryqmgceckitrcpmipcyisspdeclwmdwvtekninghqakffacikrsdgscawyrg