PDB entry 2dv0

View 2dv0 on RCSB PDB site
Description: Human Aldose Reductase complexed with zopolrestat after 6 days soaking(6days_soaked_2)
Class: oxidoreductase
Keywords: TIM barrel, OXIDOREDUCTASE
Deposited on 2006-07-28, released 2006-10-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.62 Å
R-factor: 0.187
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: aldose reductase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15121 (Start-315)
      • see remark 999 (4)
    Domains in SCOPe 2.08: d2dv0a_
  • Heterogens: NAP, ZST, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2dv0A (A:)
    masrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiq
    eklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgk
    effpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykp
    avnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaak
    hnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvca
    llsctshkdypfheef
    

    Sequence, based on observed residues (ATOM records): (download)
    >2dv0A (A:)
    srillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiqek
    lreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgkef
    fpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykpav
    nqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaakhn
    kttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvcall
    sctshkdypfheef