PDB entry 2dtg

View 2dtg on RCSB PDB site
Description: Insulin receptor (IR) ectodomain in complex with fab's
Class: hormone receptor/immune system
Keywords: insulin receptor; ir ectodomain; x-ray crystallography, hormone receptor-immune system complex
Deposited on 2006-07-12, released 2006-09-19
Made obsolete by 4zxb on 2016-02-24

The last revision prior to the SCOPe 2.07 freeze date was dated 2016-02-24, with a file datestamp of 2016-02-19.
Experiment type: XRAY
Resolution: 3.8 Å
R-factor: N/A
AEROSPACI score: 0.03 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fab 83-7 heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 2DTG (0-219)
    Domains in SCOPe 2.07: d2dtga1
  • Chain 'B':
    Compound: fab 83-7 light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 2DTG (0-218)
    Domains in SCOPe 2.07: d2dtgb1, d2dtgb2
  • Chain 'C':
    Compound: fab 83-14 heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 2DTG (0-214)
    Domains in SCOPe 2.07: d2dtgc1, d2dtgc2, d2dtgc3
  • Chain 'D':
    Compound: fab 83-14 light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 2DTG (0-213)
    Domains in SCOPe 2.07: d2dtgd1
  • Chain 'E':
    Compound: Insulin receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06213
      • engineered (143)
      • see remark 999 (841-842)
    Domains in SCOPe 2.07: d2dtge1, d2dtge2, d2dtge3, d2dtge4, d2dtge5, d2dtge6

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2dtgA (A:)
qvqlkesgpglvapsqslsitctvsgfpltaygvnwvrqppgkglewlgmiwgdgntdyn
salksrlsiskdnsksqvflkmnslqtddtaryycardpygskpmdywgqgtsvtvssak
ttppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdly
tlsssvtvpsstwpsetvtcnvahpasstkvdkkivprdc

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2dtgB (B:)
divmsqspsslvvsvgekvtmsckssqsllyssnqknflawyqqkpgqspklliywastr
esgvpdrftgsgsgtdftltissvkaedlavyycqqyfryrtfgggtkleikradaaptv
sifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysm
sstltltkdeyerhnsytceathktstspivksfnrgec

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2dtgC (C:)
qvqlqqsgpelvkpgalvkisckasgytftnydihwvkqrpgqglewigwiypgdgstky
nekfkgkatltadkssstaymhlssltseksavyfcarewaywgqgtlvtvsaakttaps
vyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytlsss
vtvpsstwpsetvtcnvahpasstkvdkkivprdc

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2dtgD (D:)
diqmtqspsslsaslgervsltcrasqdiggnlywlqqgpdgtikrliyatssldpgvpk
rfsgsrsgsdysltisslksedfvdyyclqyssspwtfgggtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrgec

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2dtgE (E:)
hlypgevcpgmdirnnltrlhelencsvieghlqillmfktrpedfrdlsfpklimitdy
lllfrvygleslkdlfpnltvirgsrlffnyalvifemvhlkelglynlmnitrgsvrie
knnelcylatidwsrildsvednhivlnkddneecgdicpgtakgktncpatvingqfve
rcwthshcqkvcptickshgctaeglcchseclgncsqpddptkcvacrnfyldgrcvet
cpppyyhfqdwrcvnfsfcqdlhhkcknsrrqgchqyvihnnkcipecpsgytmnssnll
ctpclgpcpkvchllegektidsvtsaqelrgctvingsliinirggnnlaaeleanlgl
ieeisgylkirrsyalvslsffrklrlirgetleignysfyaldnqnlrqlwdwskhnlt
itqgklffhynpklclseihkmeevsgtkgrqerndialktngdqascenellkfsyirt
sfdkillrwepywppdfrdllgfmlfykeapyqnvtefdgqdacgsnswtvvdidpplrs
ndpksqnhpgwlmrglkpwtqyaifvktlvtfsderrtygaksdiiyvqtdatnpsvpld
pisvsnsssqiilkwkppsdpngnithylvfwerqaedselfeldyclkglklpsrtwsp
pfesedsqkhnqseyedsageccscpktdsqilkeleessfrktfedylhnvvfvprpsr
krrslgdvgnagnneehrpfekvvnkeslvisglrhftgyrielqacnqdtpeercsvaa
yvsartmpeakaddivgpvtheifennvvhlmwqepkepnglivlyevsyrrygdeelhl
cdtrkhfalergcrlrglspgnysvriratslagngswteptyfyvtdyldvpsnia

    Sequence, based on observed residues (ATOM records): (download) 
    >2dtgE (E:)
pgevcpgmdirnnltrlhelencsvieghlqillmfktrpedfrdlsfpklimitdylll
frvygleslkdlfpnltvirgsrlffnyalvifemvhlkelglynlmnitrgsvrieknn
elcylatidwsrildsvednhivlnkddneecgdicpgtakgktncpatvingqfvercw
thshcqkvcptickshgctaeglcchseclgncsqpddptkcvacrnfyldgrcvetcpp
pyyhfqdwrcvnfsfcqdlhhkcknsrrqgchqyvihnnkcipecpsgytmnssnllctp
clgpcpkvchllegektidsvtsaqelrgctvingsliinirggnnlaaeleanlgliee
isgylkirrsyalvslsffrklrlirgetleignysfyaldnqnlrqlwdwskhnltitq
gklffhynpklclseihkmeevsgtkgrqerndialktngdqascenellkfsyirtsfd
killrwepywppdfrdllgfmlfykeapyqnvtefdgqdacgsnswtvvdidpplrsndp
ksqnhpgwlmrglkpwtqyaifvktlvtfsderrtygaksdiiyvqtdatnpsvpldpis
vsnsssqiilkwkppsdpngnithylvfwerqaedselfeldyclkglklpsehrpfekv
vnkeslvisglrhftgyrielqacnqdtpeercsvaayvsartmpeakaddivgpvthei
fennvvhlmwqepkepnglivlyevsyrrygdeelhlcdtrkhfalergcrlrglspgny
svriratslagngswteptyfyvtdyl