PDB entry 2dsq

View 2dsq on RCSB PDB site
Description: Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins
Class: protein binding/hormone/growth factor
Keywords: IGF, IGFBP, Insulin, PROTEIN BINDING/HORMONE/GROWTH FACTOR COMPLEX
Deposited on 2006-07-05, released 2006-08-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.292
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Insulin-like growth factor-binding protein 4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2dsqa_
  • Chain 'B':
    Compound: Insulin-like growth factor-binding protein 4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2dsqb_
  • Chain 'C':
    Compound: Insulin-like growth factor IB
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2dsqc_
  • Chain 'G':
    Compound: Insulin-like growth factor-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2dsqg1
  • Chain 'H':
    Compound: Insulin-like growth factor-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2dsqh_
  • Chain 'I':
    Compound: Insulin-like growth factor IB
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2dsqi_

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2dsqA (A:)
    deaihcppcseeklarcrppvgceelvrepgcgccatcalglgmpcgvytprcgsglrcy
    pprgvekplhtlmhgqgvcmelaeieaiqesl
    

    Sequence, based on observed residues (ATOM records): (download)
    >2dsqA (A:)
    eaihcppcseeklarcrppvgceelvrepgcgccatcalglgmpcgvytprcgsglrcyp
    prgvekplhtlmhgqgvcmelaeieaiqesl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2dsqB (B:)
    deaihcppcseeklarcrppvgceelvrepgcgccatcalglgmpcgvytprcgsglrcy
    pprgvekplhtlmhgqgvcmelaeieaiqesl
    

    Sequence, based on observed residues (ATOM records): (download)
    >2dsqB (B:)
    aihcppcseeklarcrppvgceelvrepgcgccatcalglgmpcgvytprcgsglrcypp
    rgvekplhtlmhgqgvcmelaeieaiq
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >2dsqC (C:)
    gpetlcgaelvdalqfvcgdrgfyfnkptgygsssrrapqtgivdeccfrscdlrrlemy
    caplkpaksa
    

    Sequence, based on observed residues (ATOM records): (download)
    >2dsqC (C:)
    petlcgaelvdalqfvcgdrgfyfnkpttgivdeccfrscdlrrlemycap
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >2dsqG (G:)
    vtnikkwkepcrielyrvveslakaqetsgeeiskfylpncnkngfyhsrqcetsmdgea
    glcwcvypwngkripgspeirgdpncqiyfnvqn
    

    Sequence, based on observed residues (ATOM records): (download)
    >2dsqG (G:)
    epcrielyrvveslakaskfylpncnkngfyhsrqcetsmeaglcwcvypwngkripgsp
    eirgdpncqiyfn
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >2dsqH (H:)
    vtnikkwkepcrielyrvveslakaqetsgeeiskfylpncnkngfyhsrqcetsmdgea
    glcwcvypwngkripgspeirgdpncqiyfnvqn
    

    Sequence, based on observed residues (ATOM records): (download)
    >2dsqH (H:)
    kepcrielyrvveslfylpncnkngfyhsrqcglcwcvypwngkripgspeirgdpnc
    

  • Chain 'I':
    Sequence, based on SEQRES records: (download)
    >2dsqI (I:)
    gpetlcgaelvdalqfvcgdrgfyfnkptgygsssrrapqtgivdeccfrscdlrrlemy
    caplkpaksa
    

    Sequence, based on observed residues (ATOM records): (download)
    >2dsqI (I:)
    petlcgaelvdalqfvcgdrgfyfnkgivdeccfrscdlrrlemycapl