PDB entry 2dsq

View 2dsq on RCSB PDB site
Description: Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins
Class: protein binding/hormone/growth factor
Keywords: IGF, IGFBP, Insulin, PROTEIN BINDING/HORMONE/GROWTH FACTOR COMPLEX
Deposited on 2006-07-05, released 2006-08-22
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.292
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Insulin-like growth factor-binding protein 4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2dsqa_
  • Chain 'B':
    Compound: Insulin-like growth factor-binding protein 4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2dsqb_
  • Chain 'C':
    Compound: Insulin-like growth factor IB
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2dsqc_
  • Chain 'G':
    Compound: Insulin-like growth factor-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2dsqg1
  • Chain 'H':
    Compound: Insulin-like growth factor-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2dsqh_
  • Chain 'I':
    Compound: Insulin-like growth factor IB
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2dsqi_

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2dsqA (A:)
deaihcppcseeklarcrppvgceelvrepgcgccatcalglgmpcgvytprcgsglrcy
pprgvekplhtlmhgqgvcmelaeieaiqesl

    Sequence, based on observed residues (ATOM records): (download) 
    >2dsqA (A:)
eaihcppcseeklarcrppvgceelvrepgcgccatcalglgmpcgvytprcgsglrcyp
prgvekplhtlmhgqgvcmelaeieaiqesl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2dsqB (B:)
deaihcppcseeklarcrppvgceelvrepgcgccatcalglgmpcgvytprcgsglrcy
pprgvekplhtlmhgqgvcmelaeieaiqesl

    Sequence, based on observed residues (ATOM records): (download) 
    >2dsqB (B:)
aihcppcseeklarcrppvgceelvrepgcgccatcalglgmpcgvytprcgsglrcypp
rgvekplhtlmhgqgvcmelaeieaiq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2dsqC (C:)
gpetlcgaelvdalqfvcgdrgfyfnkptgygsssrrapqtgivdeccfrscdlrrlemy
caplkpaksa

    Sequence, based on observed residues (ATOM records): (download) 
    >2dsqC (C:)
petlcgaelvdalqfvcgdrgfyfnkpttgivdeccfrscdlrrlemycap

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >2dsqG (G:)
vtnikkwkepcrielyrvveslakaqetsgeeiskfylpncnkngfyhsrqcetsmdgea
glcwcvypwngkripgspeirgdpncqiyfnvqn

    Sequence, based on observed residues (ATOM records): (download) 
    >2dsqG (G:)
epcrielyrvveslakaskfylpncnkngfyhsrqcetsmeaglcwcvypwngkripgsp
eirgdpncqiyfn

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >2dsqH (H:)
vtnikkwkepcrielyrvveslakaqetsgeeiskfylpncnkngfyhsrqcetsmdgea
glcwcvypwngkripgspeirgdpncqiyfnvqn

    Sequence, based on observed residues (ATOM records): (download) 
    >2dsqH (H:)
kepcrielyrvveslfylpncnkngfyhsrqcglcwcvypwngkripgspeirgdpnc

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >2dsqI (I:)
gpetlcgaelvdalqfvcgdrgfyfnkptgygsssrrapqtgivdeccfrscdlrrlemy
caplkpaksa

    Sequence, based on observed residues (ATOM records): (download) 
    >2dsqI (I:)
petlcgaelvdalqfvcgdrgfyfnkgivdeccfrscdlrrlemycapl