PDB entry 2dew

View 2dew on RCSB PDB site
Description: Crystal structure of human peptidylarginine deiminase 4 in complex with histone H3 N-terminal tail including Arg8
Class: hydrolase
Keywords: histone modification enzyme, HYDROLASE
Deposited on 2006-02-18, released 2006-04-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.206
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 10-mer peptide from histone H3
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 2DEW
  • Chain 'X':
    Compound: Protein-arginine deiminase type IV
    Species: Homo sapiens [TaxId:9606]
    Gene: PADI4, PADI5, PDI5
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UM07 (Start-670)
      • engineered (652)
    Domains in SCOPe 2.08: d2dewx1, d2dewx2, d2dewx3
  • Heterogens: CA, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'X':
    Sequence, based on SEQRES records: (download) 
    >2dewX (X:)
gplgspefmaqgtlirvtpeqpthavcvlgtltqldicssapedctsfsinaspgvvvdi
ahsppakkkstgsstwpldpgvevtltmkaasgstgdqkvqisyygpktppvkallylta
veislcaditrtgkvkptravkdqrtwtwgpcgqgaillvncdrdnlessamdceddevl
dsedlqdmslmtlstktpkdfftnhtlvlhvarsemdkvrvfqatrgklsskcsvvlgpk
wpshylmvpggkhnmdfyvealafpdtdfpglitltislldtsnlelpeavvfqdsvvfr
vapwimtpntqppqevyacsifenedflksvttlamkakcklticpeeenmddqwmqdem
eigyiqaphktlpvvfdsprnrglkefpikrvmgpdfgyvtrgpqtggisgldsfgnlev
sppvtvrgkeyplgrilfgdscypsndsrqmhqalqdflsaqqvqapvklysdwlsvghv
deflsfvpapdrkgfrlllasprscyklfqeqqneghgeallfegikkkkqqkiknilsn
ktlrehnsfvercidwnrellkrelglaesdiidipqlfklkefskaeaffpnmvnmlvl
gkhlgipkpfgpvingrccleekvcslleplglqctfindfftyhirhgevhagtnvrrk
pfsfkwwnmvp

    Sequence, based on observed residues (ATOM records): (download) 
    >2dewX (X:)
qgtlirvtpeqpthavcvlgtltqldicssapctsfsinaspgvvvditwpldpgvevtl
tmkaasgstgdqkvqisyygpktppvkallyltaveislcaditrtgkqrtwtwgpcgqg
aillvncdrdnlessamdceddevldsedlqdmslmtlstktpkdfftnhtlvlhvarse
mdkvrvfqatcsvvlgpkwpshylmvpggkhnmdfyvealafpdtdfpglitltislldt
snlelpeavvfqdsvvfrvapwimtpntqppqevyacsifenedflksvttlamkakckl
ticpeeenmddqwmqdemeigyiqaphktlpvvfdsprnrglkefpikrvmgpdfgyvtr
gpqtggisgldsfgnlevsppvtvrgkeyplgrilfgdscypsndsrqmhqalqdflsaq
qvqapvklysdwlsvghvdeflsfvpapdrkgfrlllasprscyklfqeqqneghgeall
fegikkkkqqkiknilsnktlrehnsfvercidwnrellkrelglaesdiidipqlfklk
efskaeaffpnmvnmlvlgkhlgipkpfgpvingrccleekvcslleplglqctfindff
tyhirhgevhagtnvrrkpfsfkwwnmvp