PDB entry 2cne

View 2cne on RCSB PDB site
Description: Structural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B
Class: hydrolase
Keywords: polymorphism, phosphorylation, protein phosphatase, endoplasmic reticulum, oxidation, hydrolase, acetylation, phosphatase
Deposited on 2006-05-21, released 2006-09-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tyrosine-protein phosphatase non-receptor type 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18031 (7-End)
    • PDB 2CNE (1-6)
    Domains in SCOPe 2.08: d2cnea2, d2cnea3
  • Heterogens: DFJ, SO4, BOG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2cneA (A:)
mhhhhhhemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdh
sriklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvm
ekgslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhf
hyttwpdfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclll
mdkrkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgdssvqdqwkel
shed

    Sequence, based on observed residues (ATOM records): (download) 
    >2cneA (A:)
mhhhhhhemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdh
sriklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvm
ekgslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhf
hyttwpdfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclll
mdkrkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfi