PDB entry 2cn8
View 2cn8 on RCSB PDB site
Description: crystal structure of human chk2 in complex with debromohymenialdisine
Class: transferase
Keywords: ATP-binding, transferase, kinase domain, phosphorylation, tumour suppressor, activation segment, li-fraumeni syndrome, serine/threonine-protein kinase, chk2, cds1, rad53, chek2, kinase, cancer, checkpoint, nucleotide-binding, hypothetical protein
Deposited on
2006-05-18, released
2006-06-28
The last revision prior to the SCOPe 2.05 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-31.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.207
AEROSPACI score: 0.26
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: serine/threonine-protein kinase chk2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d2cn8a_ - Heterogens: MG, NO3, DBQ, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2cn8A (A:)
gplgshmsvypkalrdeyimsktlgsgacgevklaferktckkvaikiiskrkfaigsar
eadpalnveteieilkklnhpciikiknffdaedyyivlelmeggelfdkvvgnkrlkea
tcklyfyqmllavqylhengiihrdlkpenvllssqeedclikitdfghskilgetslmr
tlcgtptylapevlvsvgtagynravdcwslgvilficlsgyppfsehrtqvslkdqits
gkynfipevwaevsekaldlvkkllvvdpkarftteealrhpwlqdedmkrkfqdllsee
nestalpqvlaqpstsrkrpregeaegae
Sequence, based on observed residues (ATOM records): (download)
>2cn8A (A:)
ypkalrdeyimsktlgsevklaferktckkvaikiisknveteieilkklnhpciikikn
ffdaedyyivlelmeggelfdkvvgnkrlkeatcklyfyqmllavqylhengiihrdlkp
envllssqeedclikitdfghskiltslmrtlcptylapevlvsvgtagynravdcwslg
vilficlsgyppfsehvslkdqitsgkynfipevwaevsekaldlvkkllvvdpkarftt
eealrhpwlqdedmkrkfqdllseen