PDB entry 2cn5

View 2cn5 on RCSB PDB site
Description: crystal structure of human chk2 in complex with ADP
Class: transferase
Keywords: transferase, kinase, kinase domain, checkpoint, cancer, tumour suppressor, chek2, chk2, cds1, rad53, phosphorylation, activation segment, li-fraumeni syndrome, ATP-binding, cell cycle, disease mutation, magnesium, metal-binding, nuclear protein, nucleotide-binding, proto-oncogene, serine/threonine-protein kinase
Deposited on 2006-05-18, released 2006-06-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.201
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine/threonine-protein kinase chk2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2CN5 (Start-6)
    • Uniprot O96017 (7-End)
    Domains in SCOPe 2.08: d2cn5a1, d2cn5a2
  • Heterogens: CL, MG, NO3, ADP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2cn5A (A:)
gplgshmsvypkalrdeyimsktlgsgacgevklaferktckkvaikiiskrkfaigsar
eadpalnveteieilkklnhpciikiknffdaedyyivlelmeggelfdkvvgnkrlkea
tcklyfyqmllavqylhengiihrdlkpenvllssqeedclikitdfghskilgetslmr
tlcgtptylapevlvsvgtagynravdcwslgvilficlsgyppfsehrtqvslkdqits
gkynfipevwaevsekaldlvkkllvvdpkarftteealrhpwlqdedmkrkfqdllsee
nestalpqvlaqpstsrkrpregeaegae

    Sequence, based on observed residues (ATOM records): (download) 
    >2cn5A (A:)
hmsvypkalrdeyimsktlgsgacgevklaferktckkvaikiiskrnveteieilkkln
hpciikiknffdaedyyivlelmeggelfdkvvgnkrlkeatcklyfyqmllavqylhen
giihrdlkpenvllssqeedclikitdfghskilgetslmrtlcgtptylapevlvsvgt
agynravdcwslgvilficlsgyppfsehrtqvslkdqitsgkynfipevwaevsekald
lvkkllvvdpkarftteealrhpwlqdedmkrkfqdllseene