PDB entry 2cmb
View 2cmb on RCSB PDB site
Description: Structural Basis for Inhibition of Protein Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics
Class: hydrolase
Keywords: polymorphism, phosphorylation, protein phosphatase, endoplasmic reticulum, oxidation, hydrolase, acetylation, phosphatase
Deposited on
2006-05-04, released
2006-08-17
The last revision prior to the SCOPe 2.07 freeze date was dated
2017-07-05, with a file datestamp of
2017-06-30.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.41
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: tyrosine-protein phosphatase non-receptor type 1
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P18031 (7-End)
- PDB 2CMB (1-6)
Domains in SCOPe 2.07: d2cmba2, d2cmba3 - Heterogens: F17, BOG, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2cmbA (A:)
mhhhhhhemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdh
sriklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvm
ekgslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhf
hyttwpdfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclll
mdkrkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgdssvqdqwkel
shed
Sequence, based on observed residues (ATOM records): (download)
>2cmbA (A:)
mhhhhhhemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdh
sriklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvm
ekgslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhf
hyttwpdfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclll
mdkrkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfi