PDB entry 2clt

View 2clt on RCSB PDB site
Description: crystal structure of the active form (full-length) of human fibroblast collagenase.
Class: hydrolase
Keywords: extracellular matrix, fibroblast collagenase, zinc, calcium, zymogen, protease, collagen, autocatalytic cleavage, matrix metalloproteinases, hydrolase, polymorphism, glycoprotein, metal-binding, inhibitor-free, metalloprotease, collagen degradation
Deposited on 2006-04-29, released 2006-08-09
The last revision prior to the SCOP 1.75 freeze date was dated 2006-08-30, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.67 Å
R-factor: 0.223
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: interstitial collagenase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03956 (0-366)
      • engineered mutation (119)
    Domains in SCOP 1.75: d2clta1, d2clta2
  • Chain 'B':
    Compound: interstitial collagenase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03956 (0-366)
      • engineered mutation (119)
    Domains in SCOP 1.75: d2cltb1, d2cltb2
  • Heterogens: CA, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2cltA (A:)
fvltegnprweqthltyrienytpdlpradvdhaiekafqlwsnvtpltftkvsegqadi
misfvrgdhrdnspfdgpggnlahafqpgpgiggdahfdederwtnnfreynlhrvaaha
lghslglshstdigalmypsytfsgdvqlaqddidgiqaiygrsqnpvqpigpqtpkacd
skltfdaittirgevmffkdrfymrtnpfypevelnfisvfwpqlpngleaayefadrde
vrffkgnkywavqgqnvlhgypkdiyssfgfprtvkhidaalseentgktyffvankywr
ydeykrsmdpgypkmiahdfpgighkvdavfmkdgffyffhgtrqykfdpktkriltlqk
answfnc

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2cltB (B:)
fvltegnprweqthltyrienytpdlpradvdhaiekafqlwsnvtpltftkvsegqadi
misfvrgdhrdnspfdgpggnlahafqpgpgiggdahfdederwtnnfreynlhrvaaha
lghslglshstdigalmypsytfsgdvqlaqddidgiqaiygrsqnpvqpigpqtpkacd
skltfdaittirgevmffkdrfymrtnpfypevelnfisvfwpqlpngleaayefadrde
vrffkgnkywavqgqnvlhgypkdiyssfgfprtvkhidaalseentgktyffvankywr
ydeykrsmdpgypkmiahdfpgighkvdavfmkdgffyffhgtrqykfdpktkriltlqk
answfnc